Research on the Human Conceptus and its Regulation in Britain Today

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Henderson C.J. , Braude P.R. , Aitken R.J. Polyclonal antibodies to a 32 kD deglycosylated polypeptide from porcine zonae pellucidae will prevent human gamete interaction in vitro. Gamete Research 1988; 18: 251

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Pickering S.J. , Braude P.R. , Johnson M.H. , Cant A. , Currie J. Transient cooling to room temperature can cause irreversible disruption of the meiotic spindle in the human oocyte. Fertil Steril 1990 (in press)

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Hardy K. , Hooper M.A.K. , Handyside A.H. , Rutherford A.J. , Winston R.M.L. , Leese H.J. Non-invasive measurement of glucose and pyruvate uptake by individual human oocytes and preimplantation embryos. Hum Reprod 1989; 4: 188–91

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Bolton V.N. , Oades P.J. , Johnson M.H. The relationship between cleavage, DNA replication and gene expression in the mouse 2-cell embryo. J Embryol Exp Morph 1984; 79: 139–63

Braude P. , Bolton V. , Moore S. Human gene expression first occurs between the four- and eight-cell stages of preimplantation development. Nature 1988; 332: 459–61

Saiki R.K. , Scharf S. , Faloona F. Enzymatic amplification of beta-globin genomic sequences and restriction site analysis for diagnosis of sickle cell anaemia. Science 1985; 230: 1350–4

Monk M. , Handyside A.H. , Hardy K. , Whittingham D.G. Preimplantation diagnosis of deficiency in hypoxanthine phosphoribosyl transferase in a mouse model for Lesch-Nyhan syndrome. Lancet 1987; ii: 423–5

Monk M. , Muggleton-Harris A. , Rawlings E. , Whittingham D.G. Preimplantation diagnosis of HPRT-deficient male and carrier female mouse embryos by trophectoderm biopsy. Hum Reprod 1988; 3: 377–81

Holding C. , Monk M. Diagnosis of beta thalassaemia by polymerase chain reaction: amplification of DNA in single blastomeres from mouse preimplantation embryos. Lancet 1989; ii: 532–5

Coutelle C. , Williams C. , Handyside A. , Hardy K. , Winston R. , Williamson R. Genetic analysis of DNA from single human oocytes: a model for preimplantation diagnosis of cystic fibrosis. Br Med J 1989; 299: 22–24

Handyside A.H. , Pattinson J.K. , Penketh R.J.A. , Delhanty J.D.A. , Winston R.M.L. , Tuddenham E.G.D. Biopsy of human preimplantation embryos and sexing by DNA amplification. Lancet 1989; i: 347–9

Archbishop of York. Hansard 15 January 1988: 1459–63