Nine of 122 patients dead from AIDS in central London presented with neurological disease, confirmed pathologically in seven. Seven had no other major systemic manifestations. AIDS needs to be considered in the differential diagnosis of meningitis, dementia, diffuse and focal encephalopathies, brainstem syndromes, myelopathy, visual failure and peripheral nerve syndromes. As AIDS becomes more widespread there will be an increasing need for diagnostic HIV testing in many neurological syndromes.
GillonR.Testing for HIV without permission. Br Med J1987; 294: 821–3.
2.
SniderW.D., SimpsonD.M., NielsenS.Neurological complications of acquired immune deficiency syndrome: Analysis of 50 patients. Ann Neurol1983; 14: 403–18.
3.
LevyR.M., BredesenD.E., RosenblumM.L.Neurological manifestations of the acquired immunodeficiency syndrome (AIDS): Experience at UGSF and review of the literature. J Neurosurg1985; 62: 475–95.
LevyR.M., JanssenR.S., BushT.J., RosenblumM.L.Neuroepidemiology of the acquired immune deficiency syndrome. In: RosenblumM.L., LevyR.M., BredesenD.E., eds. AIDS and the nervous system.New York: Raven Press, 1988: 13–28
6.
BergerJ.R., MoskowitzL., FischiM.Neurologie disease as the presenting manifestation of the acquired immunodeficiency syndrome. South Med J1987; 80: 673–86.
7.
GuiloffR.J., FullerG.N., RobertsA.Nature, incidence and prognosis of neurological involvement in the acquired immunodeficiency syndrome in Central London. Postgrad Med J1988; 64: 919–25.
ScaravilliF., DanielS.E., Harcourt-WebsterJ.N., GuiloffR.J.Chronic basal meningitis and vasculitis in acquired immunodeficiency syndrome. A possible role for human immunodeficiency virus. Arch Pathol Lab Med1989; 113: 192–5.
10.
DickJ.R., GuiloffR.J., StewartA.Mini-mental state examination in neurological patients. J Neurol Neurosurg Psychiatry1984; 47: 496–9.
11.
EidelbergD., SortelA., VogelH.Progressive polyradiculopathy in the acquired immune deficiency syndrome. Neurology1986; 36: 912–16.
12.
CornblathD.R., McArthurJ.C., KennedyG.E.Inflammatory demyelinating peripheral neuropathies associated with Human T lymphotrophic virus type III infection. Ann Neurol1987; 21: 32–40.
13.
LipkinI., ParryG., KirpovD.Inflammatory neuropathy in homosexual men with lymphadenopathy. Neurology1985; 35: 1479–83.
14.
DalakasM.C., PezeshkpourG.H., GravellM.Polymyositis associated with AIDS retrovirus. JAMA1986; 256: 2381–3.
15.
KovaksJ.A., KovaksA.A., PolieM.Cryptococcus in the acquired immunodeficiency syndrome. Ann Intern Med1985; 103: 533–8.
16.
LevyR.M., BredesenD.E.Central nervous system dysfunction in acquired immunodeficiency syndrome. In: RosenblumM.L., LevyR.M., BredesenD.E., eds. AIDS and the nervous system.New York: Raven Press, 1988: 29–65
17.
HoD.D., RotaT.R., SchooleyR.T.Isolation of HTLV III from cerebrospinal fluid and neural tissues of patients with neurologic syndromes related to the acquired immunodeficiency syndrome. N Engl J Med1985; 313: 1493–7.
18.
CDC. Revision of CDC surveillance case definition of acquired immunodeficiency syndrome. MMWR1987; 36(suppl 1S): 3–15
19.
NaviaB.A., PetitoC.K., GoldJ.W.M.Cerebral toxoplasmosis complicating the acquired immune deficiency syndrome: clinical and neuropathological findings in 27 patients. Ann Neurol1986; 19: 224–38.
20.
De La PazR., EnzmannD.Neuroradiology of acquired immune deficiency syndrome. In: RosenblumM.L., LevyR.M., BredesenD.E., eds. AIDS and the nervous system.New York: Raven Press, 1988: 121–55
21.
BergerJ.R., KaszovitzB., PostJ.D.Progressive Multifocal Leukodystrophy associated with human immunodeficiency virus infection; a review of the literature with a report of 16 cases. Ann Intern Med1987; 107: 78–87.
22.
NaviaB.A., JordanB.D., PriceR.W.The AIDS dementia complex 1: clinical features. Ann Neurol1986; 19: 517–24.
23.
AndersK.H., GuerraW.F., TomiyasuU.The neuropathology of AIDS: UCLA experience. Am J Pathol1986; 124: 537–58.
24.
Kennedy PGE. Neurological complications of varicella-zoster virus. In: KennedyP.G.E., JohnsonR.T., eds. Infections of the nervous system.London: Butterworths, 1987: 177–208
25.
PetitoC.K., NaviaB.A., ChoE.S.Vacuolar myelopathy pathologically resembling subacute combined degeneration in the acquired deficiency syndrome. N Engl J Med1985; 312: 974–9.
26.
TuckerT., DixR.D., KatzE.N.C.Cytomegalovirus and herpes simplex virus acute ascending myelitis in a patient with acquired immune deficiency syndrome. Ann Neurol1985; 18: 74–9.
27.
GrossniklausH.E., FrankK.E., TomsakR.L.Cytomegalovirus retinitis and optic neuritis in acquired immune deficiency syndrome. Ophthalmology1987; 94: 1601–4.
HollandG.N., SidikaroY., KreigerA.E.Treatment of cytomegalovirus retinopathy with gancyclovir. Ophthalmology1987; 94: 815–23.
30.
HollandG.N., KreigerA.E.Neuroophthalmology of the acquired immune deficiency syndrome. In: RosenblumM.L., LevyM.R., BredesenD.E., eds. AIDS and the nervous system.New York: Raven Press, 1988: 103–20
