Despite the well known effects of chronic alcohol abuse on the gastrointestinal, cardiovascular, nervous and endocrine systems, little information is available on its effect on renal function. To assess renal function we measured urinary excretion of albumin, α1 microglobulin and retinol binding protein in 30 chronic alcoholic patients. Our data shows that 40% of chronic alcoholic patients have impaired renal tubular function.
De MarchiS, CecchinE, GrimaldiF.Reduced renal phosphate threshold concentration in chronic alcoholics: One component of a more complex tubule dysfunction?Miner Electrolyte Metab1986; 12: 147–8
4.
De MarchiS, CecchinE, GrimaldiF, BasileA, Dell'AnnaL, TesioF.Reversible tubular dysfunction in alcohol abuse. Proc EDTA-ERA1984; 21: 866–74
5.
LabibM, MarksV. Hypophosphataemic osteomalacia and alcoholism: a possible link. Alcohol Alcohol1988; 23: 111–4
6.
PetersonPA, EvrinPE, BerggaardI.Differentiation of glomerular, tubular, and normal proteinuria: Determinations of urinary excretion of B2-microglobulin, albumin and total protein. J Clin Invest1969; 48: 1189–98
7.
YuH, YanagisawaY, ForbesM, CooperE, CrocksonR, MacLennanI.Alpha-1-microglobulin: An indicator protein for renal tubular function. J Clin Pathol1983; 36: 253–9
BernardA, VyskocilA, MahieuP, LaurerysR.Assessment of urinary retinol-binding protein as an index of proximal tubular injury. Clin Chem1987; 36: 775–9
10.
SumpisB, MaackT.Kinetics, competition and selectivity of tubular asborption of proteins. Am J Physiol1982; 243: 379–92
11.
WilkinsonSP, PormanB, HurstD, WilliamsR.Pathogenesis of renal failure in cirrhosis and fulminant hepatic failure. Postgrad Med J1975; 51: 303–5
12.
AmodioA, MerkelF, ZuinM, RuolA.Evaluation of renal tubular damage in liver cirrhosis by urinary enzymes and beta-2-microglobulin excretions. Eur J Clin Invest1981; 11: 293–43
13.
HedR, LundmarkC, FahlgrenH. Acute muscular syndrome in chronic alcoholism. Acta Med Scand1962; 171: 585–99
14.
PerkoffG, HardyP, Velez-GarciaE.Reversible acute muscular syndrome in chronic alcoholism. N Engl J Med1966; 274: 1277–85
15.
LalorB, FranceM, PowellD. Bone and mineral metabolism and chronic alcoholic abuse. Q J Med1986; 229: 497–511
16.
BarzelU.Parathyroid hormone, blood phosphorus, and acid-base metabolism. Lancet1971; i: 1329–31
17.
AgusZ, GardnerL, BeckL, GoldmanM.Effects of parathyroid hormone on renal tubular reabsorption of calcium, sodium and phosphate. Am J Physiol1973; 224: 1143–8