Preliminary Data Suggest a Role for Bacterial Superinfection of a Viral Keratitis after Zosteriform Spread of Herpes Simplex virus to the Eye of the Mouse
After inoculation of herpes simplex virus (HSV) on the snout of the mouse, spread to the eye occurs via neural pathways. The keratitis which ensued was clinically atypical for a pure herpetic keratitis, leading to a search for other causative agents. Preliminary data suggests that bacteriological superinfection of the viral keratitis occurs frequently, producing a unique experimental model.
TeagueO., GoodpastureE.W.Experimental herpes zoster. J Med Res1923; 44: 185–200
2.
BlythW.A., HarbourD.A., HillT.J.Pathogenesis of zosteriform spread of herpes simplex virus in the mouse. J Gen Virol1984; 65: 1477–1486
3.
ShimeldC., EastyD.L., TulloA.B., BlythW.A., HillT.J.Spread of herpes simplex virus to the eye following cutaneous inoculation in the skin of the snout of the mouse. In MaudgalP.C., MissotenL. eds. Documenta ophthalmologica proceedings series 44 herpetic eye diseases.Dordrecht: Kluwer Academic Publishers/Dr W Junk, 1985: 39–45
4.
ClaouéC.M.P., HillT.J., BlythW.A., EastyD.L.Clinical findings after zosteriform spread of herpes simplex virus to the eye of the mouse. Curr Eye Res1987; 6: 281–6
5.
HillT.J., FieldH.J., BlythW.A.Acute and recurrent infection with herpes simplex virus in the mouse: A model for studying latency and recurrent disease. J Gen Virol1975; 28: 341–53
6.
CowanS.T.Cowan and Steel's Manual for the identification of Medical Bacteria, 2nd edn.Cambridge: Cambridge University Press, 1974
7.
ClaouéC.M.P.A new look at experimental herpes simplex eye disease. Preliminary results of clinical disease after zosteriform spread to the eye in the NIH mouse. Trans Ophthalmol Soc UK1986; 105: 401–3
8.
ClaouéC.M.P., HodgesT.J., HillT.J., BlythW.A., EastyD.L.The histology of the eye after zosteriform spread of herpes simplex virus in the mouse. Br J Exp Pathol1987; 68: 585–93
9.
AndersonJr., FieldH.J.An animal model of ocular herpes; keratitis, retinitis and cataract in the mouse. Br J Exp Pathol1984; 64: 283–97
10.
RussellR.G., NassisseM.P., LarsenH.S., RouseB.T.Role of t-lymphocytes in the pathogenesis of herpetic stromal keratitis. Invest Ophthalmol Vis Sci1984; 25: 938–44
MaudgalP.C., de ClercqK., DescampsJ., MisotenL.Topical treatment of experimental herpes simplex kera-touveitis with 2′-0-glycylacyclovir. Arch Ophthalmol1984; 102: 140–2
13.
MeyersR.L., PettitT.H.The pathogenesis of corneal inflammation due to herpes simplex virus. I. Corneal hypersensitivity in the rabbit. J. Immunol1983; 111: 1031–42
14.
ShimeldC., Lewkowicz-MossS., LipworthK.M., HillT.J., BlythW.A., EastyD.L.Antigens of herpes simplex virus in whole corneal epithelial sheets from mice. Arch Ophthalmol1986; 104: 1830–4
15.
ShimeldC., DysonH., Lewkowicz-MossS., HillT.J., BlythW.A., EastyD.L.Spread of HSV1 to the mouse eye after inoculation in the skin requires an intact nerve supply to the inoculation site. Curr Eye Res1987, 6: 9–12
16.
MetcalfJ.F., MichaelisB.Herpetic keratitis in inbred mice. Invest Ophthalmol Vis Sci1984; 25: 1222–5
17.
TashiroM., CiborowskiP., KlenkH-D, PulvererG., RottR.Role of Staphylococcus protease in the development of influenza pneumonia. Nature1987; 325: 536–7
18.
WilhelmusK.R.Suppurative corneal ulceration following herpetic keratitis. Documenta ophthalmologica1982; 53: 17–36
