Brain Transplantation — Still Fantasy? Discussion Paper

Backlund EO Granberg PO Hamberger B , Transplantation of adrenal medullary tissue to striatum in parkinsonism. J Neurosurg 1985; 62: 169–73

Thompson WG . Successful brain grafting. N Y Med J 1890; 51: 701–2

Dunn EH . Primary and secondary findings in a series of attempts to transplant cerebral cortex in the albino rat. J Comp Neurol 1917; 27: 565–82

Murphy JE Sturm E . Conditions determining the transplantability of tissues in the brain. J Exp Med 1923; 38: 183–97

Greene HSN Arnold H . The homologous and heterologous transplantation of brain and brain tumors. J Neurosurg 1945; 2: 315–31

Olsen L Seiger A Stromberg I . Intraocular transplantation in rodents. A detailed account of the procedure and examples of its use in neurobiology with special reference to brain tissue grafting. In: Federoff S Hertz L , eds. Advances in cellular neurobiology, vol 4. New York: Academic Press, 1983: 407–42

Hoffer BJ Seiger A Freedman R , Electrophysiology and cytology of hippocampal formation transplants in the anterior chamber of the eye. II Cholinergic mechanisms. Brain Res 1977; 119: 107–32

Olsen L Seiger A Hoffer B , Isolated catecholaminergic projections from substantia nigra and locus coeruleus to caudate, hippocampus and cerebral cortex formed by intraocular sequential double brain grafts. Exp Brain Res 1979; 35: 47–67

Perlow MF Freed WF Hoffer BJ , Brain grafts reduce motor abnormalities produced by destruction of nigrostriatal dopamine system. Science 1979; 204: 643–7

Freed WJ . Functional brain tissue transplantation: Reversal of lesion induced rotation by intraventricular substantia nigra and adrenal medulla grafts with a note on intracranial retinal grafts. Biol Psychiatry 1983; 18: 1205–67

Stromberg I Johnson S Hoffer B , Reinnervation of dopamine denervated striatum by substantia nigra transplants: Immunohistochemical and electrophysiological correlates. Neuroscience 1985; 14: 981–90

Gash D Sladek JR Jr . Vasopressin neurons grafted into Brattleboro rats: Viability and activity. Peptides (Fayetteville) 1980; 1: 11–14

Krieger DT Perlow MJ Gibson MJ , Brain grafts reverse hypogonadism of gonadotropin-releasing hormone deficiency. Nature 1982; 298: 468–71

Perlow MJ . The brain and subarachnoid space as possible sites for endocrine tissue transplantation. Brain Res Bull 1981; 6: 171–6

Stenevi U Bjorklund A Dunnett SB . Functional reinnervation of the denervated neostriatum by nigral transplants. Peptides 1980 (Suppl 1): 111–6

Bjorklund A Stenevi U Schmidt RH , Intracerebral grafting of neuronal cell suspensions. I Introduction and general methods of preparation. Acta Physiol Scand 1983; 522 (Suppl): 1–7

Bjorklund A Gage FH Stenevi U , Intracerebral grafting of neuronal cell suspensions. VI Survival and growth of intrahippocampal implants of septal cell suspensions. Acta Physiol Scand 1983; 522 (Suppl): 49–58

Low WC Lewis PR Bunch ST , Functional recovery following neural transplantation of embryonic septal nuclei in adult rats with septohippocampal lesions. Nature 1982; 300: 260–2

Kromer LF Bjorklund A Stenevi U . Intracephalic embryonic neural implants in the adult rat brain. I Growth and mature organisation of brainstem, cerebellar and hippocampal implants. J Comp Neurol 1983; 218: 433–59

Gash DM Boer GJ , Cholinergic neurons transplanted into the neocortex and hippocampus of primates; studies on African green monkeys. In: Bjorklund A Stenevi U , eds. Neural grafting in the mammalian CNS. Amsterdam: Elsevier, 1985: 595–603

Rosenstein JM Brightman MW . Intact cerebral ventricle as a site for tissue transplantation. Nature 1978; 275: 83–5

Zalewski AA . Prolonged survival and trophic function of neurons in homologous transplants of sensory ganglion in vivo. Exp Neurol 1971; 30: 510–24

Molinoff PB Axelrod JA . Biochemistry of catecholamines. Ann Rev Biochem 1971; 40: 465–500

Unsicker K Reiffert B Ziegler W . Effects of cell culture conditions, nerve growth factor, dexamethasone and cyclic AMP on adrenal chromaffin cells in vitro. In: Frank O eds. Histochemistry and cell biology of autonomic neurons, SIF cells and paraneurons. New York: Raven Press, 1980: 27–34, 51–9 (Advances in Biochemical Psychopharmacology vol 25).

Tischler AS Greene LA . Phenotypic plasticity of phaeochromocytoma and normal adrenal medullary cells. In: Frank O eds. Histochemistry and cell biology of autonomic neurons, SIF cells and paraneurons. New York: Raven Press, 1980: 61–68 (Advances in Biochemical Psychopharmacology, vol 25)

Bottenstein JE . Differentiated properties of neuronal cells lines. In: Sato GH , ed. Functionally differentiated cell lines. New York: Alan Liss, 1981: 155–84

Nelson PG Peacock JH Amano T , Electrogenesis in mouse neuroblastoma cells in vitro. J Cell Physiol 1970; 77: 337–52

Ogawa M Ishikawa T Irimajiri A . Adrenal chromaffin cells form functional cholinergic synapses in culture. Nature 1984; 307: 66–8

Bjorklund A Stenevi U Dunnett SB , Cross-species grafting in a rat model of Parkinson's disease. Nature 1982; 298: 652–4

Morihisa JM Nakamura RK Freed WJ , Adrenal medulla grafts survive and exhibit catecholamine-specific fluorescence in the primate brain. Exp Neurol 1984; 84: 643–53

Langston JW Ballard P Tetrud JW , Chronic Parkinosinism in humans due to a product of meperidine analogue synthesis. Science 1983; 219: 979–80

Burns RS Chiueh CC Markey SP , A primate model of Parkinsonism: Selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-MPTP. Proc Natl Acad Sci USA 1983; 80: 4546–50

Dunnett SB Bjorklund A Gage FH , Transplantation of mesencephalic dopamine neurons to the striatum of adult rats. In: Bjorklund A Stenevi U , eds. Neural grafting in the mammalian CNS. Amsterdam: Elsevier Science, 1985: 451–69

Davies P Maloney AJF . Selective loss of central cholinergic neurons in Alzheimer's disease. Lancet 1976; ii: 1403

Bowen DM Smith CB White P , Neurotransmitter-related enzymes and indices of hypoxia in senile dementia and other brain atrophies. Brain 1976; 99: 459–96

Whitehouse PJ Price DL Struble RG , Alzheimer's disease and senile dementia: Loss of neurons in the basal forebrain. Science 1982; 215: 1237–9

Morrison JH Rogers J Scherr S , Somatostatin immunoreactivity in neuritic plaques of Alzheimer's patients. Nature 1985; 314: 90–2

Boyd WD Graham-White J Blackwood G , Clinical effects of choline in Alzheimer senile dementia. Lancet 1977; ii: 711–3

Das GP . Neurol transplantation in the spinal cord of adult rats. J Neurol Sci 1983; 38: 191–210

Hallas BH . Transplantation of embryonic rat spinal cord or neocortex into the intact or lesioned adult spinal cord. Appl Neurophysiol 1984; 47: 43–50