A histological study of 21 teeth from 9 patients who had received cytotoxic chemotherapy for malignant disease showed increased prominence of incremental lines in the dentine. The number and distribution of these lines corresponded to periods of intravenous therapy and vincristine appeared to be the most likely cause. This effect was probably due to temporary disturbance of microtubular function in the odontoblasts resulting in decreased secretion of collagenous dentine matrix. Calcification appeared to be unaffected.
WelburyR.R., CraftA.N., MurrayJ.J., KernahanJ.. Dental health of survivors of malignant disease.Arch Dis Child1984; 59: 1186–7
5.
BerryC.L., GermainJ.P.. Polygenic models in teratological testing. In: BerryC.L., PoswilloD.E.. Teratology. Trends and applications.Berlin: Springer-Verlag, 1975: 83–102
6.
AdatiaA.K.. Response of the dental elements to chemotherapy of Burkitt's tumour.Int Dent J1968; 18: 646–53
7.
EurlichH.P., RossR., BornsteinP.. Effects of antimicrotubular agents on the secretion of collagen.J Cell Biol1974; 62: 390–405
8.
MoskalenskiS., ThybergJ., LohmanderS., FribergU.. Influence of colchicine and vinblastine on the golgi-complex and matrix deposition in chondrocyte aggregates.Exp Cell Res1975; 95: 440–54
9.
SteneT., KoppangH.S.. The effect of vincristine on dentinogenesis in the rat incisor.Scand J Dent Res1976; 84: 342–4
10.
SteneT., KoppangH.S.. Autoradiographic investigation of dentine production in rate incisors after vincristine administration.Scand J Dent Res1980; 88: 104–12
11.
JenkinsG.N.. The physiology and biochemistry of the mouth.4th ed.Oxford: Blackwell Scientific, 1978: 223–6
