A double-blind controlled trial of 12 months' treatment with (+)-cyanidanol-3 was carried out in 26 patients with chronic hepatitis B liver disease. Treatment did not improve liver blood tests nor histological appearances of the liver, but there was a trend towards reduction of serum titres of hepatitis B surface antigen.
SchalmSWHeytinkRAvan BuurenHRde ManRA. Acyclovir enhances the antiviral effect of interferon in chronic hepatitis B. Lancet1985; ii: 358–60
2.
SagnelliEPiccininoFManzilloG, Effect of immunosuppressive therapy on HBsAg-positive chronic active hepatitis in relation to presence or absence of HBeAg and anti-HBe. Hepatology1983; 3: 690–5
3.
BlumALBerthetPDoelleW, Treatment of acute viral hepatitis with (+)-cyanidanol-3. Lancet1977; ii: 1153–5
4.
Di NolaF. (+)-cyanidanol-3 in acute viral hepatitis. Lancet1980; ii: 1379
5.
SchomerusHWiedmannKHDölleW, (+)-cyanidanol-3 in the treatment of acute viral hepatitis: A randomized controlled trial. Hepatology1984; 4: 331–5
6.
PiazzaMde MercatoRGuadagninoVPicciotoLAbresiaNChirianniAGoldenG. Effect of (+)-cyanidanol-3 on chronic persistent and chronic active hepatitis. In: ConnHO, ed. International workshop on (+)-cyanidanol-3 in diseases of the liver. London: Royal Society of Medicine and Academic Press, 1981: 123–9 (RSM International Congress and Symposium Series, No. 47)
7.
DemeulenaereFDesmetVJDupontE, Study of (+)-cyanidanol-3 in chronic active hepatitis. In: ConnHO, ed. International workshop on (+)-cyanidanol-3 in diseases of the liver. London: Royal Society of Medicine and Academic Press, 1981: 135–41 (RSM International Congress and Symposium Series, No. 47)
ParAPaalMKadasIKerekesEJavorT. Effect of (+)-cyanidanol-3 (Catergen) in chronic active hepatitis. Acta Med Hung1983; 40: 17–24
10.
Bar-MeirSHalpernZGutmanMShpirerZBaratzMBassD. Effect of (+)-cyanidanol-3 on chronic active hepatitis: A double blind controlled trial. Gut1985; 26: 975–9
