The Placebo Effect and Long History of the Habit of Belief. How a Medieval Image Reveals the Power of the Invisible

Evers AWM Colloca L Blease C Annoni M Atlas LY Benedetti F , et al. Implications of placebo and nocebo effects for clinical practice: expert consensus. Psychother Psychosom 2018; 87: 204–210. DOI: 10.1159/000490354.

Podolsky SH. The (Harry) gold standard: angina, suggestion, and the path to the “double-blind” test and clinical pharmacology. J R Soc Med 2023; 116: 246–251. DOI: 10.1177/01410768231183237.

Kam-Hansen S Jakubowski M Kelley JM Kirsch I Hoaglin DC Kaptchuk TJ , et al. Altered placebo and drug labeling changes the outcome of episodic migraine attacks. Sci Transl Med 2014; 6: 218ra215. DOI: 10.1126/scitranslmed.3006175.

Flaten MA Simonsen T Olsen H. Drug-related information generates placebo and nocebo responses that modify the drug response. Psychosom Med 1999; 61: 250–255. DOI: 10.1097/00006842-199903000-00018.

Colloca L Lopiano L Lanotte M Benedetti F. Overt versus covert treatment for pain, anxiety, and Parkinson’s disease. Lancet Neurol 2004; 3: 679–684. DOI: 10.1016/S1474-4422(04)00908-1.

Hjorth OR Frick A Gingnell M Hoppe JM Faria V Hultberg S , et al. Expectancy effects on serotonin and dopamine transporters during SSRI treatment of social anxiety disorder: a randomized clinical trial. Transl Psychiatry 2021; 11: 559. DOI: 10.1038/s41398-021-01682-3.

Atlas LY Whittington RA Lindquist MA Wielgosz J Sonty N Wager TD. Dissociable influences of opiates and expectations on pain. J Neurosci 2012; 32: 8053–8064. DOI: 10.1523/JNEUROSCI.0383-12.2012

Bingel U Wanigasekera V Wiech K Ni Mhuircheartaigh R Lee MC Ploner M , et al. The effect of treatment expectation on drug efficacy: imaging the analgesic benefit of the opioid remifentanil. Sci Transl Med 2011; 3:70ra14. DOI: 10.1126/scitranslmed.3001244

Lund K Petersen GL Erlandsen M De Pascalis V Vase L Jensen TS , et al. The magnitude of placebo analgesia effects depends on how they are conceptualized. J Psychosom Res 2015; 79: 663–668. DOI: 10.1016/j.jpsychores.2015.05.002.

Aslaksen PM Zwarg ML Eilertsen HH Gorecka MM Bjorkedal E. Opposite effects of the same drug: reversal of topical analgesia by nocebo information. Pain 2015; 156: 39–46. DOI: 10.1016/j.pain.0000000000000004

Büchel C Geuter S Sprenger C Eippert F. Placebo analgesia: a predictive coding perspective. Neuron 2014; 81: 1223–1239. DOI: 10.1016/j.neuron.2014.02.042

Kaptchuk TJ Hemond CC Miller FG. Placebos in chronic pain: evidence, theory, ethics, and use in clinical practice. BMJ 2020; 370: m1668. DOI: 10.1136/bmj.m1668.

Wandel LP . The moment of communion. In: Green M Nørgaard LC Bruun MB (eds.) Early Modern Privacy. Sources and Approaches. Leiden/Boston: Brill, 2022: 159–178. (Intersections; 78).

Wormatiensis B (Burchard of Worms) (1853). Decretum. in: Patrologia Latina, ed. Migne J. P. , Paris vol. 140.

Rubin M. Corpus Christi: The Eucharist in Late Medieval Culture. Cambridge: Cambridge University Press, 1991.

Izbicki TM. The Eucharist in Medieval Canon Law. Cambridge: Cambridge University Press, 2015.

Arnold J. Belief and Unbelief in Medieval Europe. London: Hodder Arnold, 2005.

Bonaventura. Breviloquium. In: Bonaventura, Tria opuscula. Collegii S. Bonaventurae. ed. Ad Claras Aquas (Quaracchi): Collegium Sancti Bonaventurae, 1911: 7–285.

Aquinas T. Summa theologiae, secunda pars secundae partis, in: Corpus Thomisticum. See https://www.corpusthomisticum.org/sth3001.html (last checked 22 May 2026).

Bonaventura. In tertium librum sententiarum. In: Bonaventura, Opera omnia, 10 volumes, ed., Ad Claras Aquas (Quaracchi): Collegium Sancti Bonaventurae. 1887; 1885–1902, vol. 3.

Gerson J , De parvulis ad Christum trahendis. In: Œuvres Complètes, ed. Glorieux Paris P. , 1973: 669–686.

Clark A. Whatever next? Predictive brains, situated agents, and the future of cognitive science. Behav Brain Sci 2013; 36: 181–204.

Clark A. Hacking the predictive mind. Entropy 2024; 26: 677. DOI: 10.3390/e26080677.

Pfändtner K-G . Das Gebetbuch des Johann Siebenhirter in Stockholm. Geschichte – Ausstattung – Bedeutung. Carinthia I. Mitteilungen des Geschichtsvereins für Kärnten. 2007; 197: 107–156.

Gow AC. The Red Jews: Antisemitism in an apocalyptic age, 1200–1600. Leiden/New York: E.J. Brill, 1995.

Kumler A . Counterfeiting the Eucharist in late medieval life and art. In: Melion WS Pastan EC Wandel LP (eds.) Quid est Sacramentum? Visual Representation of Sacred Mysteries in Early MODERN EUROPE, 1400–1700. Leiden/Boston: Brill, 2020: 57–81.

Hamburger J. Bosch’s “Conjuror”: an attack on magic and sacramental heresy. Simiolus 1984; 14: 4–23. DOI: 10.2307/3780529.

Kirakosian R Möllenbrink L Zamore G Kaptchuk T Jensen K. Heresy, witchcraft, Jean Gerson, scepticism and the use of placebo controls. J R Soc Med 2024; 117: 36–41. DOI: 10.1177/01410768231207260.

Marson Smith P Colquhoun D Chalmers I . John Henry Gaddum’s 1940 guidance on controlled clinical trials. J R Soc Med 2019; 112: 394–400. DOI: 10.1177/0141076819870674.

Kaptchuk TJ. A brief history of the evolution of methods to control observer biases in tests of treatments. JLL Bull: Comment History of Treat Eval. Epub ahead of print 2011. https://www.jameslindlibrary.org/articles/a-brief-history-of-the-evolution-of-methods-to-control-of-observer-biases-in-tests-of-treatments/ (last checked 22 May 2026).

Chalmers I Dukan E Podolsky S Davey Smith G. The advent of fair treatment allocation schedules in clinical trials during the 19th and early 20th centuries. J R Soc Med 2012; 105: 221–227.