Controlled Trials Testing two or More Treatments Simultaneously

Wyckoff J. , Dubois E.F. , Woodruff I.O. The therapeutic value of digitalis in pneumonia. JAMA 1930; 95: 1243–9

Wilson C. , Pollock M.R. , Harris A.D. Diet in the treatment of infectious hepatitis. Lancet 1946; i: 881–3

Medical Research Council Streptomycin In Tuberculosis Trials Committee. Streptomycin treatment for pulmonary tuberculosis. BMJ 1948; 2: 769–2

Doll R. Medical treatment of gastric ulcers. Scott Med J 1964; 9: 183–96

Doll R. , Pygott F. Factors influencing the rate of healing of gastric ulcers: admission to hospital, phenobarbitone, and ascorbic acid. Lancet 1952; i: 171–5

Chalmers T.C. , Eckhart R.D. , Reynolds W.E. . The treatment of acute infectious hepatitis. Controlled studies of the effects of diet, rest, and physical reconditioning on the acute course of the disease and on the incidence of relapses and residual abnormalities. J Clin Invest 1955; 34: 1163–234

ISIS-1 Collaborative Group. Randomised trial of intravenous atenolol among 16,027 cases of suspected acute myocardial infarction: ISIS-1. Lancet 1986; ii: 57–66

ISIS-2 Collaborative Group. Randomised trial of intravenous streptokinase, oral aspirin, both, or neither among 17187 cases of suspected acute myocardial infarction: ISIS-2. Lancet 1988; ii: 349–60

ISIS-4 Collaborative Group. A randomised factorial trial assessing early captopril, oral mononitrate, and intravenous magnesium sulphate in 58,050 patients with suspected acute myocardial infarction. Lancet 1995; 345: 669–85