How relevant are animal models to human ageing?

Sprott RL , Austad SN. Animal models for aging research. Handbook of the Biology of Aging. New York: Academic Press, 1996

Goyns MH , Charlton MA , Dunford JE Differential display analysis of gene expression indicates that age-related changes are restricted to a small cohort of genes. Mech Age Dev 1998; 108: 73–90

Epstein CJ , Avraham KB , Lovett M Transgenic mice with increased Cu/Zn-superoxide dismutase activity: animal model of dosage effects in Down syndrome. Proc Natl Acad Sci USA 1987; 84: 8044–8

Ornitz DM , Palmiter RD , Hammer RE , Brinster RL , Swift GH , MacDonald RJ. Specific expression of an elastase-human growth hormone fusion gene in pancreatic acinar cells of transgenic mice. Nature 1985; 313: 600–2

Van Deursen J , Heerschap A , Oerlemans F Skeletal muscles of mice deficient in muscle creatine kinase lack burst activity. Cell 1993; 74: 621–33

Moran PM , Higgins LS , Cordell B , Moser PC. Age-related learning deficits in transgenic mice expressing the 751-amino acid isoform of human β-amyloid precursor protein. Proc Natl Acad Sci USA 1995; 92: 5341–5

Games D , Adams D , Alessandrini R Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein. Nature 1995; 373: 523–7

Cutler RG , Davis BJ , Ingram DK , Roth GS. Plasma concentrations of glucose, insulin, and percent glycosylated hemoglobin are unaltered by food restriction in rhesus and squirrel monkeys. J Gerontol 1992; 47: B9–B12

Kemnitz JW , Weindruch R , Roecker EB Dietary restriction of adult rhesus monkeys: design, methodology, and preliminary findings from the first year of study. J Gerontol 1993; 48: B17–B26

Bons N , Mestre N , Petter A. Senile plaques and neurofibrillary changes in the brain of aged lemurian primate. Neurobiol Aging 1992; 13: 99–105

Nowak RM. Mammals of the World. Baltimore: Johns Hopkins University Press, 1991

Adams MR , Bond MG. Benign prostatic hyperplasia in a squirrel monkey (Saimiri sciureus). Lab Anim Sci 1979; 29: 674–6

Jurgens KD , Prothero J. Scaling of maximal lifespan in bats. Comp Bioehem Physiol 1987; 88A: 361–7

Nowak RM , Parádiso JL. Walker's Mammals of the World. Vols. 1-2: Baltimore: Johns Hopkins University Press, 1983

Austad SN , Fischer KE. Mammalian aging, metabolism and ecology: evidence from the bats and marsupials. J Gerontol 1991; 46: B47–B55

Lindstedt SL , Calder WA. Body size and longevity in birds. Condor 1976; 78: 91–4

Finch CE. Longevity, Senescence, and the Human Genome. Chicago: University of Chicago Press, 1990

Adelman R , Saul RL , Ames BN. Oxidative damage to DNA: relation to species metabolic rate and life span. Proc Natl Acad Sci USA 1988; 85: 2706–8

Agarwal S , Sohal RS. Relationship between susceptibility to protein oxidation, aging, and maximum life span potential of different species. Exp Gerontol 1996; 31: 387–92

Sell DR , Lane MA , Johnson WA Longevity and the genetic determination of collagen glycoxidation kinetics in mammalian senescence. Proc Natl Acad Sci USA 1996; 93: 485–90

Grube K , Burkle A. Poly (ADP-ribose) polymerase activity in mononuclear leukocytes of 13 mammalian species. Proc Natl Acad Sci USA 1992; 89: 11759–63

Sohal RS , Weindruch R. Oxidative stress, caloric restriction, and aging. Science 1996; 273: 59–63

Kapahi P , Boulton ME , Kirkwood TBL. Positive correlation between mammalian life span and cellular resistance to stress. Free Rad Biol Med 1999; 26: 495–500