Outcomes research can play an important role in the development and
evolution of the specialty practice of nutrition support. This manuscript
discusses the current state and future prospect of outcomes research in
specialized nutrition support. It is concluded that there is an important role
in the field for research that focuses on “what works, and what does
not” in nutrition support practice.
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References
1.
August DA. Creation of a specialized nutrition support outcomes
research consortium: if not now, when? JPEN J Parenter Enteral
Nutr.1996;20:394–
400.
2.
Tannenbaum SJ. What physicians know. N Engl J
Med.1993; 329:1268–
1270.
Developing an agenda for patient outcomes research in HIV diesease.
Forum for Collaborative HIV Research, Department of Prevention and Community
Health, School of Public Health and Health Services. September 1999. Available
at:
http://www.hivforum.org/publications/develop_agenda.pdf.
Accessed June 11, 2007.
August DA. Nutrition support research: it is our obligation to do
better. JPEN J Parenter Enteral Nutr.2004
;28:201–
209.
7.
McWhirter JP. Incidence and recognition of malnutrition in
hospital. BMJ.1994
;308:945–
948.
8.
Bistrian BR, Blackburn GL, Vitale J, Cochran D, Naylor J.
Prevalence of malnutrition in general medical patients.
JAMA.1976;235:1567–
1570.
9.
DeWys WD, Begg C, Lavin PT, et al. Prognostic effect of weight loss
prior to chemotherapy in cancer patients: Eastern Cooperative Oncology Group.
Am J Med.1980;69:491–
497.
10.
Veterans Affairs Total Parenteral Nutrition Cooperative Study
Group. Perioperative total parenteral nutrition in surgical patients: the
Veterans Affairs Total Parenteral Nutrition Cooperative Study Group.
N Engl J Med.1991
;325:525–
532.
11.
Sacks H, Chalmers TC, Smith H Jr. Randomized versus historical
controls for clinical trials. Am J Med.1982
;72:233–
240.
12.
Concato J, Shah N, Horwitz RI. Randomized, controlled trials,
observational studies, and the hierarchy of research designs. N
Engl J Med.2000;342:1887–
1892.
13.
Tucker HN, Miguel SG. Cost containment through nutrition
intervention. Nutr Rev.1996
;54:111–
121.
14.
Adams S, Dellinger EP, Wertz MJ, Oreskovich MR, Simonowitz D,
Johansen K. Enteral versus parenteral nutritional support following laparotomy
for trauma: a randomized prospective trial. J Trauma Injury Infect
Crit Care.1986;26:882–
891.
15.
Moore FA, Moore EE, Jones TN, McCroskey BL, Peterson VM. TEN versus
TPN following major abdominal trauma: reduced septic morbidity. J
Trauma Injury Infect Crit Care.1989
;29:916–
923.
16.
Kudsk KA, Croce MA, Fabian TC, et al. Enteral versus parenteral
feeding: effects on septic morbidity after blunt and penetrating abdominal
trauma. Ann Surg.1992
;215:503–
511; discussion 511–513.
17.
Wolfe BM, Mathiesen KA. Clinical practice guidelines in nutrition
support: can they be based upon randomized clinical trials? JPEN J
Parenter Enteral Nutr.1997
;21:1–
6.
18.
Dalen JE, Bone RC. Is it time to pull the pulmonary artery
catheter? [editorial]. JAMA.1996
;276:916–
918.
19.
Maliakkal RJ, Blackburn GL, Willcutts HD, et al. Optimal design of
clinical outcome studies in nutrition and cancer: future directions.
JPEN J Parenter Enteral Nutr.1992
;16(6 Suppl):112S–
116S.
20.
Moses LE. Measuring effects without randomized trials? Options,
problems, challenges. Med Care.1995
;33(4 Suppl):AS8–
AS14.
21.
Park RE, Brook RH, Kosecoff J, et al. Explaining variations in
hospital death rates: randomness, severity of illness, quality of care.
JAMA.1990;264:484–
490.
22.
Blumberg MS. Risk adjusting health care outcomes: a methodologic
review. Med Care Rev.1986
;43:351–
393.
23.
Roos LL, Sharp SM, Cohen MM, Wajda A. Risk adjustment in
claims-based research: the search for efficient approaches. J Clin
Epidemiol.1989;42:1193–
1206.
24.
Rontal R, Kiess MJ, DesHarnais S, Reutter K. Applications for
risk-adjusted outcome measures. Qual Assur Health
Care.1991; 3:283–
292.
25.
DesHarnais S, McMahon LF Jr, Wrobleski R. Measuring outcomes of
hospital care using multiple risk-adjusted indexes. Health Serv
Res.1991;26:425–
445.
26.
Connors AF, Speroff T, Dawson NV, et al. The effectiveness of right
heart catheterization in the initial care of critically ill patients: SUPPORT
Investigators. JAMA.1996
;276:889–
897.
27.
Van den Berghe G, Wouters P, Weekers F, et al. Intensive insulin
therapy in critically ill patients. N Engl J Med.2001
;345:1359–
1367.
28.
Bouillon R. Intensive insulin therapy in the medical ICU.
N Engl J Med.2006
;354:449–
461.
29.
Van den Berghe G, Wouters PJ, Bouillon R, et al. Outcome benefit of
intensive insulin therapy in the critically ill: insulin dose versus glycemic
control. Crit Care Med.2003
;31:359–
366.
30.
Heyland DK, Drover JW, Jain M, Su X, Suchner U. Should
immunonutrition become routine in critically ill patients? A systematic review
of the evidence. JAMA.2001
;286:944–
953.
31.
Heyland DK, Dhaliwal R, Drover JW, Gramlich L, Dodek P. Canadian
clinical practice guidelines for nutrition support in mechanically ventilated,
critically ill adult patients. JPEN J Parenter Enteral
Nutr.2003;27:355–
373.
32.
Bistrian BR, McCowen KC. Nutritional and metabolic support in the
adult intensive care unit: key controversies. Crit Care
Med. 2006;34:1525–
1531.
33.
Simpson F, Doig G. Parenteral vs. enteral nutrition in the
critically ill patient: a meta-analysis of trials using the intention to treat
principle. Intensive Care Med.2005
;31:12–
23.
34.
Heyland DK, Dhaliwal R, Day A, Jain M, Drover J. Validation of the
Canadian clinical practice guidelines for nutrition support in mechanically
ventilated, critically ill adult patients: results of a prospective,
observational study. Crit Care Med.2004
;32:2260–
2266.
35.
Jain MK, Heyland DK, Dhaliwal R, et al. Dissemination of the
Canadian clinical practice guidelines for nutrition support: results of a
cluster randomized controlled trial. Crit Care Med.2006
;34:2362–
2369.
