Abstract
Scanning electron microscopy is a valuable technique for study ing surface changes of controlled release plaques. It is used to study the mechanism of controlled release bioactive materials from SBR binding matrix after soaking in water. Before soaking the plaque in water, the micrographs showed that there is some degree of surface homogeneity distribution of the particles encased within the binding matrix. So, there is good compatibility among the particles of the ingredients incorporated with SBR matrix. After im mersion in water, appreciable changes on the surface of the plaque occurred. In the absence of bioactive materials the swelling of the soaked binding matrix was remarkable—pores, voids, and cracks were absent. In the case of the pres ence of bioactive materials, there were observed a great number of distinct pore structures in the plaque surface and a high degree of compactness among the different particles encased within the binding matrix. Also, tortusic pass and "sponge like" structure were observed.
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