Abstract
Thirty-seven inmates who had previously volunteered for phase I drug testing and 33 who had not were interviewed by a psychologist to obtain demographic and motivational data. Each inmate completed a standard psychopathology inventory (the Minnesota Multiphasic Personality Inventory), the Similarities and Picture Arrangement subtests of the Wechsler Adult Intelligence Scale, a test of normal personality variables (the Edwards Personality Scale), and Christie's Machiavellianism Scale. The data supported the conclusions that (1) inmates are in general free enough from psychopathology to be able to make rational choices about participating in medical research as long as preliminary screening for individuals with severely disordered thinking is carried out, (2) verbal communication skills of inmates appear to be well enough developed to allow them to give an informed consent, (3) while there are personality differences between volunteers and nonvolunteers, these appear to relate most directly to the fact that, without screening, impulsive, manipulative individuals with disordered thought processes are over-represented among volunteers for medical research.
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