Abstract
The concern of this work is the statistical evaluation of healing rate of gastric ulcers. To measure healing progress, the distance of linear advance of a specific ulcer margin toward center is recommended as an appropriate parameter. The sequence of linear advances is approximately linear over time; thus, the slope of this linear profile provides a good indication of the healing rate of the specific ulcer area. To estimate the mean slope in a treatment group, the mixed effects model technique is employed. A treatment effects comparison is made by both the F-test and the likelihood ratio test for a common slope across treatments. Also discussed are the advantages of using the linear advance as an endpoint and the mixed effects model technique as an analysis tool. A numerical example is presented as an illustration.
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