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Abstract

A widely used approach to analyzing carcinogenicity assays was established by Peto et al. (1). In addition to assessing time to death and the tumor types present at death for each animal, one needs information on the cause of death for each animal to apply this kind of analysis.

The “cause of death” data appear to be very unreliable, and they tend to vary heavily between different pathologists. In other studies, they are not assessed at all, and one tends to analyze these data as if they had “time to death from tumor” instead of “time to death with tumor” information available.

In this paper, a model (see Groeneboom [2]) to analyze “time to death with tumor” data is presented. An overview of the two available sample tests will be given, and the results of a simulation study will be presented.

Keywords

Interval censoring Two-sample tests Rank tests AMS 1980 subject classification: 62 E 20 62 G 10

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References

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Analyzing Carcinogenicity Assays without Cause of Death Information

Abstract

Keywords

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References