Abstract
The nonparametric age-adjusted test proposed by Kodell and Ahn (1) for assessing dose-related trend with respect to the tumor incidence rate in animal experiments is extended from the case of multiple sacrifices to the case of a single (terminal) sacrifice. The tumor incidence rate is made identifiable for time intervals preceding the final time interval by assuming constant proportionality of the tumor prevalences in live and dead animals. Information on cause of death is not required. A Monte Carlo simulation study is conducted to assess size and power of the test.
Keywords
Get full access to this article
View all access options for this article.
