This brief review of selected work from the recent literature illustrates the critical influence processing conditions can have on the performance of pharmaceutical products. Topics covered include capsules, granulation and compression, inert matrices, and extrusion/spheronization.
UllahIWileyGJAgharkarSN. Analysis and simulation of capsule dissolution problem encountered during product scale-up. Drug Dev Ind Pharm.1992; 18:895–910.
2.
ChowhanZTAmaroAA. Optimization of tablet friability, maximum attainable crushing strength, weight variation and in vitro dissolution by establishing in-process variable controls. Drug Dev Ind Pharm.1988;14:1079–1106.
3.
GordonMS. Process considerations in reducing tablet friability and their effect on in vitro dissolution. Drug Dev Ind Pharm.1994;20:11–29.
4.
WuP. Effect of drug solubility in wet granulation fluids on the dissolution rates of the resulting tablets. Drug Dev Ind Pharm.1989;15:11–16.
5.
ErtelKD. Physical aspects of wet granulation IV—effect of kneading time on dissolution rate and tablet properties. Drug Dev Ind Pharm.1990; 16: 963–981.
6.
BansalP. Effect of formulation and process variables on the dissolution profile of naproxen sodium from tablets. Drug Dev Ind Pharm.1994;20: 2151–2156.
7.
ChowhanZT. Effect of moisture and crushing strength on tablet friability and in vitro dissolution. J Pharm Sci.1982;71:1371–1375.
8.
TakeuchiHHandaTKawashimaY. Enhancement of the dissolution rate of a poorly water-soluble drug (tolbutamide) by a spray-drying solvent deposition method and disintegrants. J Pharm Pharmacol.1987;39:769–773.
9.
GouldPLTanSB. The effect of recompression on the dissolution of wet massed tablets containing ‘super’ disintegrants. Drug Dev Ind Pharm.1986;12: 1929–1945.
10.
FosterTPParrottEL. Effect of processing on release from an inert, heterogeneous matrix. Drug Dev Ind Pharm.1990;16:1309–1324.
11.
Al-KassasRSGilliganCAPoALW. Processing factors affecting particle size and in vitro drug release of sustained-release ibuprofen microspheres. Int Pharm.1993;94:59–67.
12.
DownGRB. The effect of pinholes on the dissolution behaviour of enteric-coated acetylsalicylic acid tablets. Drug Dev Ind Pharm.1993;19: 2743–2749.
13.
LiLCPeckGE. Water-based silicone elastomer controlled release tablet film coating IV. process evaluation. Drug Dev Ind Pharm.1990; 16:415–435.
14.
ZhangGSchwartzJBSchnaareRL. Effect of spheronization technique on drug release from un-coated beads. Drug Dev Ind Pharm.1990;16:1171–1184.
15.
ZhangG. Bead coating: II. Effect of spheronization technique on drug release from coated spheres. Drug Dev Ind Pharm.1991;17:817–830.
