Considerable evidence exists in humans and experimental animals to demonstrate that a qualitative relationship exists between changes in the function of the immune system and increased susceptibility to infectious or neoplastic diseases. Quantitative relationships, however, are less well established and their elucidation is needed to improve the risk assessment process. Here, some of the complex relationships between changes in immune function and tumor development are discussed and the analyses of several dataseis designed to model their quantitative association are summarized.
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