Abstract
The diagnosis, course, and therapeutic management of the benzodiazepine withdrawal syndrome is still a debated question. The correct method for clinical trials in this indication is also not yet codified. A large sample of patients is required, so the trial must be conducted on a multicenter basis. The present paper describes the main features of a protocol aimed at investigating the ability of a new nonbenzodiazepine anxiolytic drug, alpidem, in preventing or treating the benzodiazepine withdrawal syndrome. A pretrial to standardize the diagnostic and evaluation criteria to be used in the multicenter trial is described.
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