Theoretical Aspects of Drug Interactions of Interest to Drug Research Scientists and Clinicians

Hogben C. A. M. Schanker L. S. Tocco D. J. Brodie B. B. : Absorption of Drugs from the Stomach. II. The Human. J. Pharmacol. Exp. Ther. 120: 540–545, 1957.

Hogben C. A. M. Tocco D. J. Brodie B. B. Schanker L. S. : On the Mechanism of Intestinal Absorption of Drugs. J. Pharmacol. Exp. Ther. 125: 275–282, 1959.

Consolo S. Morselli P. L. Zaccala M. Garattini S. : Delayed Absorption of Phenylbutazone Caused by Desmethylimipramine in Human. Europ. J. Pharmacol. 10: 239–242, 1970.

Dearborn E. H. Litchfield J. T. Jr. Eisner H. J. Corbett J. J. Dunnett C. W. : The Effects of Various Substances on the Absorption of Tetracycline in Rats. Antibiot. Med. 4: 627–641, 1957.

Schnell R. C. Miya T. S. : Increased Ileal Absorption of Salicylic Acid Induced by Carbonic Anhydrase Inhibition. Biochem. Pharmacol. 19: 303–305, 1970.

Barr W. A. Adir J. Garrettson L. : Decrease of Tetracycline Absorption in Man by Sodium Carbonate. Clin. Pharmacol. Ther. 12: 779–784, 1971.

Hurwitz A. Sheehan M. B. : The Effects of Antacids on the Absorption of Orally Administered Pentobarbital in the Rat. J. Pharmacol. Exp. Ther. 179: 124–131, 1971.

Mullins J. D. Macek T. J. : Some Pharmaceutical Properties of Novobiocin. J. Amer. Pharm. Ass. (Sci. Ed.) 49:245–252, 1960.

Anton A. H. : The Relation Between the Binding of Sulfonamides to Albumin and Their Antibacterial Efficacy. J. Pharmacol. Exp. Ther. 129: 282–290, 1960.

Brodie B. B. Mark L. C. Papper E. M. Lief P. H. Bernstein E. Rovenstine E. A. : The Fate of Thiopental in Man and a Method for Its Estimation in Biological Material. J. Pharmacol. Exp. Ther. 99: 409–420, 1950.

Bogan J. : Effect of SKF 525-A on the Fate of Thiopentone. J. Pharm. Pharmacol. 22: 709–710, 1970.

Weiner I. M. Washington J. A. II Mudge G. H. : On the Mechanism of Action of Probenecid on Renal Tubular Secretion. Bull. Johns Hopkins Hosp. 106: 333–346, 1960.

Waddell W. J. Butler T. C. : The Distribution and Excretion of Phenobarbital. J. Clin. Invest. 36: 1217–1226, 1957.

Gerhardt R. E. Knouss R. F. Thyrum P. T. Luchi R. J. Morris J. J. Jr. : Quinidine Excretion in Aciduria and Alkuria. Ann. Intern. Med. 71: 927–933, 1969.

Davis J. M. Kopin I. J. Lemberger L. Axelrod J. : Effects of Urinary pH on Amphetamine Metabolism. Ann. N.Y. Acad. Sci. 179: 493–501, 1971.

Butler T. C. : Introduction. Termination of Drug Action by Elimination of Unchanged Drug. Symposium on Processes Terminating Drug Action. Fed. Proc. 17: 1158–1162, 1958.

Gillette J. R. : Biochemistry of Drug Oxidation and Reduction by Enzymes in Hepatic Endoplasmic Reticulum. Adv. Pharmacol. 4: 219–261, 1966.

Mannering G. J. : Inhibition of Drug Metabolism. In Handbook of Experimental Pharmacology; Vol. XXVIII Part 2. Concepts in Biochemical Pharmacology ( Brodie B. B. Gillette J. R. , Eds.), 1971, Springer-Verlag, Berlin, Heidelberg, New York, pp. 452–476.

Smuckler E. A. Arrhenius E. Hultin T. : Alterations in Microsomal Electron Transport, Oxidative N-Demethylation and Azo-Dye Cleavage in Carbon Tetrachloride and Dimethylnitrosamine-Induced Liver Injury. Biochem. J. 103: 55–64, 1967.

Kuntzman R. Sernatinger E. Jacobson M. Levin W. : Destruction of Liver Microsomal Hemoprotein by Secobarbital. Fed. Proc. 31:548 Abs., 1972.

Franklin M. R. : Cytochrome P-450 and Methylene Dioxyphenyl Metabolism. Fed. Proc. 31:548 Abs., 1972.

Tephley T. R. Hibbeln P. : The Effect of Cobalt Chloride Administration on the Synthesis of Hepatic Microsomal Cytochrome P-450. Biochem. Biophys. Res. Commun. 42: 589–595, 1971.

Conney A. H. : Pharmacological Implications of Microsomal Enzyme Induction. Pharmacol. Rev. 19: 317–366, 1967.

Ernster L. Orrenius S. : Substrate Induced Synthesis of the Hydroxylating Enzyme Systems of Liver Microsomes. Fed. Proc. 24: 1190–1199, 1965.

Lu A. Y. Kuntzman R. West S. Jacobson M. Conney A. H. : Reconstituted Liver Microsomal Enzyme System that Hydroxylates Drugs, Other Foreign Compounds, and Endogenous Substrates. II. Role of the Cytochrome P-450 and P-448 Fractions in Drug and Steroid Hydroxylations. J. Biol. Chem. 247: 1727–1734, 1972.

Stripp B. Hamrick M. E. Zampaglione N. G. Gillette J. R. : The Effect of Spironolactone on Drug Metabolism by Hepatic Microsomes. J. Pharmacol. Exp. Ther. 176: 766–771, 1971.

Conney A. H. Michaelson I. A. Burns J. J. : Stimulatory Effect of Chlorcyclizine on Barbiturate Metabolism. J. Pharmacol. Exp. Ther. 132: 202–206, 1961.

Gillette J. R. : Metabolism of Drugs and Other Foreign Compounds by Enzymatic Mechanisms. In Jucker E. (Ed.): Recent Progress in Drug Research, Basle, Burkhauser Verlag 6:13–73, 1963.

Dingell J. R. Sulser F. Gillette J. R. : Species Differences in the Metabolism of Imipramine and Desmethylimipramine (DMI). J. Pharmacol. Exp. Ther. 143: 14–22, 1964.

Marcucci F. Guaitani A. Kvetina J. Mussini E. Garattini S. : Species Difference in Diazepam Metabolism and Anticonvulsant Effect. Europ. J. Pharmacol. 4: 467–470, 1968.

Marcucci F. Mussini E. : A Metabolic Explanation of Differences Between Species of the Anticonvulsant Activity of Diazepam. Brit. J. Pharmacol. 34:667P–668P, 1968.

Marcucci F. Mussini E. Fanelli R. Garattini S. : Species Differences in Diazepam Metabolism: (1) Metabolism of Diazepam Metabolites. Biochem. Pharmacol. 19: 1847–1851, 1970.

Creaven P. J. Parke D. V. : The Stimulation of Hydroxylation by Carcinogenic and Non-Carcinogenic Compounds. Biochem. Pharmacol. 15: 7–16, 1966.

Marcucci F. Fannelli R. Mussini E. Garattini S. : Effect of Phenobarbital on the In Vitro Metabolism of Diazepam in Several Animal Species. Biochem. Pharmacol. 19: 1771–1776, 1970.

Fouts J. R. Brodie B. B. : Inhibition of Drug Metabolic Pathways by the Potentiating Agent, 2,4-Dichloro-6-Phenylphenoxyethyl Diethylamine. J. Pharmacol. Exp. Ther. 115: 68–73, 1955.

Anders M. W. Mannering G. J. : Inhibition of Drug Metabolism. I. Kinetics of the Inhibition of the N-Demethylation of Ethylmorphine by 2-Diethylaminoethyl 2,2-Diphenylvalerate HCl (SKF 525-A) and Related Compounds. Mol. Pharmacol. 2: 319–327, 1966.

Netter K. J. : Die Hemming der procainhydrolyse durch die diathylaminoathanolester der diphenylpropylessigsaure (SKF 525-A) und der diphenylessigsaur (“Trasentin”). Naunyn Schmiedeberg's Archiv. Exptl. Pathol. Pharmakol. 235: 498–512, 1959.

Netter K. J. : Discussion of Individual Variation in Drug Metabolism as a Cause of Drug Toxicity. Second International Pharmacological Meeting 4: 257–260, 1965, Brodie B. B. Gillette J. R. (Eds.), Pergamon Press.

Gillette J. R. Kamm J. J. : The Enzymatic Formation of Sulfoxides: The Oxidation of Chlorpromazine and 4,4′-Diaminodiphenyl Sulfide by Guinea Pig Liver Microsomes. J. Pharmacol. Exp. Ther. 130: 262–267, 1960.

Leibman K. C. : Effects of Metyrapone on Liver Microsomal Drug Oxidation. Mol. Pharmacol. 5: 1–9, 1969.

Sjoqvist F. Hammer W. Schumacher H. Gillette J. R. : The Effect of Desmethylimipramine and other “Antitremorine” Drugs on the Metabolism of Tremorine and Oxotremorine in Rats and Mice. Biochem. Pharmacol. 17: 915–934, 1968.

Sjoqvist F. Gillette J. : Prolongation and Potentiation of Oxotremorine Effects by Desmethylimipramine, an “Anti-Tremorine” Drug. Life Sci. 4: 1031–1036, 1965.

Welch R. M. Kocsis J. : Activation of Tremorine by Liver. Proc. Soc. Exp. Biol., N.Y. 107: 731–734, 1961.

Cho A. K. Haslett W. L. Jenden D. J. : The Identification of an Active Metabolite of Tremorine. Biochem. Biophys. Res. Commun. 5: 276–279, 1961.

Levy G. : Drug Biotransformation Interactions in Man: Nonnarcotic Analgesics. Ann. New York Acad. Sci. 179: 32–42, 1971.

De Baun J. R. Smith J. Y. R. Miller E. C. Miller J. A. : Reactivity In Vivo of the Carcinogen N-Hydroxy-2-Acetylaminofluorene: Increase by Sulfate Ion. Science 167: 184–186, 1970.

Wattenberg L. W. Leong J. L. : Histochemical Demonstration of Reduced Pyridine Nucleotide Dependent Polycyclic Hydrocarbon Metabolizing Systems. J. Histochem. Cytochem. 10: 412–420, 1962.

Burger P. C. Hudson P. B. : Phenobarbital-Induced Fine Structural Changes in Rat Liver. Ann. J. Pathol. 48: 793–809, 1966.

Brodie B. B. Reid W. D. Cho A. K. Sipes G. Krishna G. Gillette J. R. : Possible Mechanism of Liver Necrosis Caused by Aromatic Organic Compounds. Proc. Nat. Acad. Sci. 68: 160–164, 1971.

Reid W. D. Eichelbaum M. Christie B. Brodie B. B. : Mechanism of Bromobenzene Hepatotoxicity. I. Studies In Vivo. Fed. Proc. 30: 439, 1971.

Reid W. D. Christie B. Eichelbaum M. Krishna G. : 3-Methylcholanthrene Blocks Hepatic Necrosis Induced by Administration of Bromobenzene or CCl₄ . Exp. Molec. Pathol. 15: 363–372, 1971.

Zampaglione N. G. Jollow D. J. Hamrick M. E. Stripp B. Gillette J. R. : Influence of Phenobarbital and 3-Methylcholanthrene Treatment on the Metabolism of Bromobenzene in the Rat. Fed. Proc. 30: 1412, 1971.

Jollow D. J. Zampaglione N. Gillette J. R. : Mechanism of Protection from Bromobenzene Hepatotoxicity by 3-Methylcholanthrene. Pharmacologist 13: 537, 1971.

Prescott L. F. Wright N. Roscoe P. Brown S. S. : Plasma-Paracetamol Half-Life and Hepatic Necrosis in Patients with Paracetamol Overdosage. Lancet 1: 519–522, 1971.

Mitchell J. R. Potter W. Z. Jollow D. David D. C. Gillette J. R. Brodie B. B. : Acetaminophen-Induced Hepatic Necrosis. I. Potentiation by Inducers and Protection by Inhibitors of Drug-Metabolizing Enzymes. Fed. Proc. 31:539 Abs., 1972.

Potter W. Z. Davis D. C. Jollow D. Mitchell J. R. : Acetaminophen-Induced Hepatic Necrosis. II. Conditions for Covalent Binding of Acetaminophen to Hepatic Macromolecules. Fed. Proc. 31:539 Abs., 1972.

Jollow D. Potter W. Z. Hashimoto M. Davis D. C. Mitchell J. R. : Acetaminophen-Induced Hepatic Necrosis. IV. Role of Glutathione. Fed. Proc. 31:539 Abs., 1972.

Kopin I. J. Fischer J. E. Musacchio J. M. Horst W. D. Weise V. K. : False Neurochemical Transmitters and the Mechanism of Sympathetic Blockade by Monoamine Oxidase Inhibitors. J. Pharmacol. Exp. Ther. 147: 186–193, 1965.

Wiebel F. Leute J. C. Diamond L. Gelboin H. V. : Aryl Hydrocarbon (Benzo (a)pyrene) Hydroxylase in Microsomes from Rat Tissues: Differential Inhibition and Stimulation by Benzoflavones and Organic Solvents. Arch. Biochem. Biophys. 144: 78–86, 1971.

Suria A. M. Mitchell J. R. Stripp B. Jollow D. Gillette J. R. : On the Mechanism of 7, 12-Dimethylbenzanthracene-Induced Bone Marrow Damage. Pharmacologist 13: 283, 1971.

Vesell E. S. Page J. G. : Genetic Control of the Induction of an Hepatic Microsomal Drug Metabolizing Enzyme in Man. J. Clin. Invest. 48: 2202–2209, 1969.