Abstract
Objectives: To systematically assess the outcomes and effectiveness of Prescription Automatic Screening System (PASS) on rational drug use in China. Methods: All studies that evaluated the effects of PASS in Chinese hospitals were electronically searched. Meta-analysis was used to assess the outcomes of intervention effects. Results: Twelve articles that appraised the interventions related to PASS were identified. All studies used before-after designs. Risk ratio was chosen as the effect size index. Heterogeneity was large (I2 > 50%) in all main analyses. Effect sizes were pooled using random effects. Compared with the control group, the pooled effect sizes were 0.60 (95% CI, 0.52-0.70) for the outcome of the incident of inpatient irrational drug use (n = 5), 0.75 (95% CI, 0.59-0.96) for the outcome of the incident of outpatient patient irrational drug use (n = 2), and 0.29 (95% CI, 0.10-0.86) for the outcome of the incidence of black-light warning orders (n = 6). Conclusions: Interventions related to PASS was associated with the reduction of irrational drug use and medication errors.
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