The Skin and the Immune Response in Onchocerciasis

Guderian RH Beck BJ Stone DJ Isabel K Mackenzie CD . Onchocerciasis in Ecuador: Recent observations in the province of Esmeraldas. J Trop Med Hyg 1988; 91: 161–8.

World Health Organization . Expert Committee on Onchocerciasis: Third Report. Technical Report Series No. 752. WHO: Geneva, 1987:1–167.

Prost A Vaugelade J. La surmortalité des aveugles en zone de savane ouest-africaine. Bull WHO 1981; 59: 773–6.

Browne SG . Incidence and clinical manifestations of onchocerciasis in a focus in the Oriental Province of the Belgian Congo. Ann Trop Med 1959; 53: 421–9.

Wyatt GB . Onchocerciasis in Ibarapa, Western State, Nigeria. Ann Trop Med Parasital 1971; 65: 513–23.

Anderson J Fuglsang H Hamilton PJS de Marshall TFC . Studies on onchocerciasis in the United Cameroon Republic I. Comparison of populations with and without Onchocerca volvulus. Trans R Soc Trop Med Hyg 1974; 68: 190–208.

Anderson J Fuglsang H Hamilton PJS de Marshall TFC . Studies on onchocerciasis in the United Cameroon Republic II. Comparison of onchocerciasis in rain-forest and Sudan-savanna. Trans R Soc Trop Med Hyg 1974; 68: 209–22.

Fuglsang H Anderson J de Marshall TFC . Studies on onchocerciasis in the United Cameroon Republic. V. A four year follow-up of 6 rain forest and 6 Sudan-savanna villages. Some changes in skin and lymph nodes. Trans R Soc Trop Med Hyg 1979; 73: 118–19.

Omar MS Franz M Büttner DW . Some observations on onchocerciasis including Sowda in the Yemen Arab Republic. Tropenmed Parasitol 1979; 30: 113–19.

Somorin AO . Sowda onchocerciasis in Nigeria. Cent Afr J Med 1982; 28: 253–6.

Büttner DW Laer G V Mannweiler E Büttner M. Clinical, parasitological and serological studies on onchocerciasis in the Yemen Arab Republic. Tropenmed Parasitol 1982; 33: 201–12.

Edungbola LD Oni GA Aiyedun BA . Babana Parasitic Diseases Project. I. The study area and a preliminary assessment of onchocercal endemicity based on the prevalence of ‘leopard skin’. Trans R Soc Trop Med Hyg 1983; 77: 303–9.

Ghalib HW Mackenzie CD Kron MA Williams JF El Khalifa M El Sheikh H. Severe onchocercal dermatitis in the Ethiopian border region of Sudan. Ann Trop Med Parasitol 1987; 81: 405–19.

Hay RJ Mackenzie CD Guderian R Noble WC Proano JR Williams JF . Onchodermatitis — correlation between skin disease and parasitic load in an endemic focus in Ecuador. Br J Dermatol 1989; 121: 187–98.

Murdoch ME Yahaya H Njepuome N Evans J Jones BR Abiose A. Prevalence of skin changes compatible with onchocerciasis in Kaduna State, Northern Nigeria (abstract). Br J Dermatol 1991; 125(38 Suppl):37.

Onchocerciasis Control Programme, WHO. Ten years of onchocerciasis control in West Africa: review of the work of the Onchocerciasis Control Programme in the Volta River Basin area from 1974 to 1984. Geneva: World Health Organization, 1985. Document OCP/GVA/85.1B.

Pearson CA . Awareness of onchocerciasis (letter). Lancet 1986; ii: 805–6.

Glover M Murdoch M Leigh I. Subtle early features of onchocerciasis in a European. J R Soc Med 1991; 84: 435.

Duke BOL Lewis DJ Moore PJ . Onchocerca-Simulium complexes. I. Transmission of forest and Sudan-savanna strains of Onchocerca volvulus, from Cameroon, by Simulium damnosum from various West African bioclimatic zones. Ann Trop Med Parasitol 1966; 60: 318–36.

Ottesen EA . Immunological aspects of lymphatic filariasis and onchocerciasis in man. Trans R Soc Trop Med Hyg 1984; 78(Suppl):9–18.

Maizels RM Lawrence RA . Immunological tolerance: The key feature in human filariasis? Parasitol Today 1991;7:271–6.

Murdoch ME Hay RJ Ramnarain N Lucas S Jones B Abiose A. A clinical classification and grading system of the changes in onchocerciasis and histopathological findings (abstract). Br J Dermatol 1990; 123(37 Suppl):28.

Mackenzie CD Williams JF Sisley BM Steward MW O'Day J. Variations in host responses and the pathogenesis of human onchocerciasis. Rev Infect Dis 1985; 7: 802–8.

Nwoke BEB . The socio-economic aspects of human onchocerciasis in Africa: Present appraisal. J Hyg Epidemiol Microbiol Immunol 1990; 34: 37–44.

Jopling WH . Onchocerciasis presenting without dermatitis. BMJ 1960; i: 861.

Harvey RJ . The early diagnosis and treatment of onchocerciasis. Cent Afr J Med 1967; 13: 242–5.

Wolfe MS Petersen JL Neafie RC Connor DH Purtilo DT . Onchocerciasis presenting with swelling of limb. Am J Trop Med Hyg 1974; 23: 361–8.

Gibson DW Heggie C Connor DH . Clinical and pathologic aspects of onchocerciasis. Pathol Ann 1980; 15(Pt 2):195–240.

Murdoch ME Abiose A Hay RJ Ramnarain N Cerio R Jones BR . Cutaneous mesoendemic savannah onchocerciasis in Northern Nigeria: A clinico-histopathological correlation study (abstract). Br J Dermatol 1992; 127(Suppl 40):80.

Connor DH Gibson DW Neafie RC Merighi B Buck AA . Sowda-onchocerciasis in North Yemen: A clinicopathological study of 18 patients. Am J Trop Med Hyg 1983; 32: 123–37.

Edungbola LD Watts SJ Oni GA . Rapid estimation of onchocercal endemicity using ‘leopard skin’ (LS). Acta Leidensia 1990; 59: 467–8.

Browne SG . Onchocercal depigmentation. Trans R Soc Trop Med Hyg 1960; 54: 325–34.

Gibson DW Connor DH . Onchocercal lymphadenitis: Clinicopathologic study of 34 patients. Trans R Soc Trop Med Hyg 1978; 72: 137–54.

Browne SG . The role of Onchocerca volvulus in lymphadenopathy and associated conditions. Cent Afr J Med 1960; 6: 302–6.

Connor DH Morrison NE Kerdel-Vegas F Onchocerciasis: Onchocercal dermatitis, lymphadenitis, and elephantiasis in the Ubangi Territory. Hum Pathol 1970; 1: 553–79.

Bird AC Anderson J Fuglsang H. Morphology of posterior segment lesions of the eye in patients with onchocerciasis. Br J Ophthal 1976; 60: 2–20.

Anderson J Fuglsang H. Ocular onchocerciasis. Trop Dis Bull 1977; 74: 257–72.

Burnham GM . Onchocerciasis in Malawi. 2. Subjective complaints and decreased weight in persons infected with Onchocerca volvulus in the Thyolo highlands. Trans R Soc Trop Med Hyg 1991; 85: 497–500.

Prost A Nebout M Rougemont A. Lepromatous leprosy and onchocerciasis. BMJ 1979; i: 589–90.

Buck AA Anderson RI Kawata K Hitchcock JC Jr Onchocerciasis: Some new epidemiologic and clinical findings. Am J Trop Med Hyg 1969; 18: 217–30.

Buck AA Anderson RI Colston JAC Jr Microfilaruria in onchocerciasis. Bull World Health Organ 1971; 45: 353–69.

Rougemont A Boisson-Pontal ME Pontal PG Gridel F Sangare S. Tuberculin skin tests and BCG vaccination in hyperendemic area of onchocerciasis. Lancet 1977; i: 309.

Ngu JL . Immunological studies on onchocerciasis. Acta Trop 1978; 35: 269–79.

Bartlett A Turk J Ngu J Mackenzie CD Fuglsang H Anderson J. Variation in delayed hypersensitivity in onchocerciasis. Trans R Soc Trop Med Hyg 1978; 72: 372–7.

Kilian HD Nielsen G. Cell-mediated and humoral immune response to tetanus vaccinations in onchocerciasis patients. Trop Med Parasit 1989; 40: 285–91.

Kilian HD Nielsen G. Cell-mediated and humoral immune responses to BCG and rubella vaccinations and to recall antigens in onchocerciasis patients. Trop Med Parasit 1989; 40: 445–53.

Greene BM Fanning MM Ellner JJ . Non-specific suppression of antigen-induced lymphocyte blastogenesis in Onchocerca volvulus infection in man. Clin Exp Immunol 1983; 52: 259–65.

Ward DJ Nutman TB Zea-Flores G Portocarrero C Lujan A Ottesen EA . Onchocerciasis and immunity in humans: Enhanced T cell responsiveness to parasite antigen in putatively immune individuals. J Infect Dis 1988; 157: 536–43.

Gallin M Edmonds K Ellner JJ Cell mediated immune responses in human infection with Onchocerca volvulus. J Immunol 1988; 140: 1999–2007.

Greene BM Gbakima AA Albiez EJ Taylor HR . Humoral and cellular immune responses to Onchocerca volvulus infection in humans. Rev Infect Dis 1985; 7: 789–95.

Sutherland IH Campbell WC . Development, pharmacokinetics and mode of action of ivermectin. Acta Leidensia 1990; 59: 161–8.

Schulz-Key H Greene BM Awadzi K Efficacy of ivermectin on the reproductivity of female Onchocerca volvulus. Trop Med Parasit 1986; 37: 89.

Trpis M Childs JE Fryauff DJ Effect of mass treatment of a human population with ivermectin on transmission of Onchocerca volvulus by Simulium yahense in Liberia, West Africa. Am J Trop Med Hyg 1990; 42: 148–56.

Whitworth JAG Morgan D Maude GH Downham MD Taylor DW . A community trial of ivermectin for onchocerciasis in Sierra Leone: Clinical and parasitological responses to the initial dose. Trans R Soc Trop Med Hyg 1991; 85: 92–6.

Taylor HR Semba RD Newland HS Ivermectin treatment of patients with severe ocular onchocerciasis. Am J Trop Med Hyg 1989; 40: 494–500.

Philippon B Remme JH Walsh JF Guillet P Zerbo DG . Entomological results of vector control in the Onchocerciasis Control Programme. Acta Leidensia 1990; 59: 79–94.

De Sole G Remme J. Onchocerciasis infection in children born during 14 years of Simulium control in West Africa. Trans R Soc Trop Med Hyg 1991; 85: 385–90.

Dadzie KY Remme J De Sole G. Epidemiological impact of vector control II. Changes in ocular onchocerciasis. Acta Leidensia 1990; 59: 127–39.