Investigation of an outbreak of hepatitis in Dhaka implicated enterically transmitted non-A, non-B (ET-NANB) hepatitis as the etiologic agent. This observation was made by exclusion in 17 of 19 patients, and confirmed serologically in one randomly selected patient by a fluorescent antibody blocking assay specific for ET-NANB hepatitis. These findings reinforce earlier suspicions that ET-NANB may be an important cause of acute hepatitis in Bangladesh. The epidemiology of ET-NANB hepatitis is discussed, and public health recommendations are made.
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References
1.
KrawczynskiKBradleyDW. Enterically transmitted non-A, non-B hepatitis: identification of virus-associated antigen in experimentally infected cynomolgus macaques. J Infect Dis1989; 159: 1042–7.
2.
BradleyDWKrawcynskiKCookEHJrEnterically transmitted non-A, non-B hepatitis: serial passage of disease in cynomolgus macaques and tamarins and recovery of disease-associated 27- to 34-nm viruslike particles. Proc Natl Acad Sci USA1987; 84: 6277–81.
3.
WongDCPurcellRHScreenivasanMAPrasadSRPavriKM. Epidemic and endemic hepatitis in India: evidence for non-A, non-B hepatitis virus etiology. Lancet1980; ii: 876–8.
4.
KaneMABradleyDWShresthaSMEpidemic non-A, non-B hepatitis in Nepal: recovery of a possible etiologic agent and transmission studies in marmosets. JAMA1984; 252: 3140–5.
5.
MyintHSoeMMKhinTMyintTMTinKM. A clinical and epidemiological study of an epidemic of non-A, non-B hepatitis in Rangoon. Am J Trop Med Hyg1985; 34: 1183–9.
6.
MalikIAQureshiMSLuqmanMEpidemics of non-A, non-B hepatitis in Pakistan. Trop Doct1988; 18: 99–101.
7.
IslamMNIslamKMNIslamN.Hepatitis B virus infection in Dhaka, Bangladesh. Bangladesh Med Res Counc Bull1984; 10: 1–6.
8.
WaizAHossainR.Viral hepatitis — a short review and epidemiological study of a recent outbreak in Bangladesh armed forces. Bangladesh Armed Forces Med J1985; 10: 53–61.
ViswanathanR.Certain epidemiological features of infectious hepatitis during Delhi epidemic 1955–1956. In: HartmanFW, ed. Hepatitis frontiers, Henry Ford Hospital International Symposium.Boston: Little Brown & Co, 1957: 207–10.
11.
TandonBNJoshiYKJainSKGandhiBMMathiesenLRTandonHD. An epidemic of non-A, non-B hepatitis in north India. Indian J Med Res1982; 75: 739–44.
12.
KhurooMSDuermeyerWZargarSAAcute sporadic non-A, non-B hepatitis in India. Am J Epidemiol1983; 118: 360–4.
13.
MaynardJEHadlerSCFrancisDP. Epidemiology of non-A, non-B hepatitis. In: DeinhardtFDeinhardtJ, eds. Viral hepatitis: laboratory and clinical science.New York: Marcel Dekker, 1983: 231–8.
14.
BradleyDWMaynardJEPopperHPosttransfusion non-A, non-B hepatitis: physiochemical properties of two distinct agents. J Infect Dis1983; 148: 254–65.
