Leptospirosis exhibits a broad spectrum of clinical symptoms, ranging from mild fever to severe multiorgan failure. Hepatic dysfunction is common in leptospirosis and typically occurs after the prodromal phase of the disease. Jaundice in leptospirosis is due to impaired hepatocellular bilirubin excretion and bile flow disruption. However, bile duct injury leading to secondary sclerosing cholangitis (SSC) in leptospirosis is rare.
De BritoTSilvaAMGDAbreuPAE. Pathology and pathogenesis of human leptospirosis: a commented review. Rev Inst Med Trop Sao Paulo2018; 60: e23.
2.
AponsoTWanninayakeWMDASWijesingheIP, et al.Secondary sclerosing cholangitis: an unusual presentation of leptospirosis. Trop Med Health2025; 53: 20.
3.
MartinsPVerdelho MachadoM. Secondary sclerosing cholangitis in critically ill patients: an underdiagnosed entity. GE Port J Gastroenterol2020; 27: 103–114.
