High neonatal sepsis burden and limited diagnostics in low- and lower-middle-income countries (LMICs) drive empiric antibiotic use in neonatal intensive care units (NICUs), increasing antimicrobial resistance. This review examines 19 reports on efforts to kerb this trend. Importantly, reduced use was not associated with increased mortality, sepsis recurrence, necrotising enterocolitis or re-admissions.
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