Hepatic histoplasmosis presenting as portal hypertension in an immunocompetent elderly male: A multidisciplinary case report

Abstract

Histoplasmosis, caused by Histoplasma capsulatum, is a dimorphic fungus typically endemic to parts of the Americas, Africa, and Asia. Inhalational exposure leads primarily to pulmonary infection, and extrapulmonary or isolated hepatic presentations are rare, particularly in immuno-competent individuals. We present an unusual case of hepatic histoplasmosis with no evident lung involvement, highlighting a diagnostic challenge and a rewarding pathologic discovery.