Crohn's disease is a chronic granulomatous inflammatory condition affecting any part of the gastrointestinal tract. Extra-intestinal manifestations affecting the mouth may also occur, with a prevalence varying between 0.5% and 37%. However, vulval involvement is rare with approximately130 reported cases in the literature so far. An extensive literature search has shown isolated lip and vulval involvement as extra-intestinal manifestations of Crohn's disease, with only one reported case of combined vulval and lip involvement.
NiveathaMLalithaRMurugeshM, et al.Chronic vulval ulcer as Crohn's disease. J Obstet Gynaecol India2024; 74: 91–93.
2.
TanCXWde BoerNKHBrandHS. Oralemanifestaties van de ziekte van Crohn [Oral manifestations of Crohn's disease]. Ned Tijdschr Tandheelkd2018; 125: 15–20.
3.
WellsLECohenD. Delayed diagnosis of vulvar Crohn's disease in a patient with no gastrointestinal symptoms. Case Rep Dermatol2019; 10: 263–267.
4.
BoxhoornLStoofTJde MeijT, et al.Dutch Initiative on Crohn and Colitis. Clinical experience and diagnostic algorithm of vulval Crohn's disease. Eur J Gastroenterol Hepatol2017; 29: 838–843.
5.
NabatianASShahKNIofelE, et al.Asymptomatic granulomatous vulvitis and granulomatous cheilitis in childhood: the need for Crohn disease workup. J Pediatr Gastroenterol Nutr2011; 53: 100–101.
