Restricted accessResearch articleFirst published online 2026-1
Prevalence and associated risk factors of generalised anxiety disorders in children with seizure disorders in the rural population of northern India – an observational study
Our study investigated the prevalence and risk factors for generalised anxiety disorder (GAD) in children with epilepsy. A clinically significant level of anxiety was observed in 8% of children with epilepsy, especially those who are older, have frequent seizures, or have been on antiepileptic drugs for extended periods.
SinghiPGuptaA. Epilepsy in children – important facets. Indian J Peds2021; 88: 991–992.
2.
FisherRSAcevedoCArzimanoglouA, et al.ILAE official report: a practical clinical definition of epilepsy. Epilepsia2014; 55: 475–482.
3.
GeertsABrouwerOvan DonselaarC, et al.Health perception and socioeconomic status following childhood-onset epilepsy: the Dutch study of epilepsy in childhood. Epilepsia2011; 52: 2192–2202.
4.
AlfstadKÅClench-AasJVan RoyB, et al.Psychiatric symptoms in Norwegian children with epilepsy aged 8–13 years: effects of age and gender?Epilepsia2011; 52: 1231–1238.
5.
StevanovicDJancicJLakicA. The impact of depression and anxiety disorder symptoms on the health-related quality of life of children and adolescents with epilepsy. Epilepsia2011; 52: e75–e78.
6.
RantanenKErikssonKNieminenP. Cognitive impairment in preschool children with epilepsy. Epilepsia2011; 52: 1499–1505.
7.
TaylorJJacobyABakerGA, et al.Self-reported and parent reported quality of life of children and adolescents with new-onset epilepsy. Epilepsia2011; 52: 1489–1498.
8.
AlwashRHHusseinMJMatloubFF. Symptoms of anxiety and depression among adolescents with seizures in Irbid, Northern Jordan. Seizure2000; 9: 412–416.
9.
OttDCaplanRGuthrieD, et al.Measures of psychopathology in children with complex partial seizures and primary generalized epilepsy with absence. J Am Acad Child Adolesc Psych2001; 40: 907–914.
10.
AdewuyaAOOlaBA. Prevalence of and risk factors for anxiety and depressive disorders in Nigerian adolescents with epilepsy. Epilepsy Behav2005; 6: 342–347.
11.
CaplanRSiddarthPGurbaniS, et al.Depression and anxiety disorders in pediatric epilepsy. Epilepsia2005; 46: 720–730.
12.
JonesJEWatsonRShethR, et al.Psychiatric comorbidity in children with new onset epilepsy. Develop Med Child Neurol2007; 49: 493–497.
13.
ShahABannerNHeginbothamC, et al.Diagnostic and statistical manual of mental disorders. 5th ed. Arlington: American Psychiatric Publishing, 2013.
FisherRSCrossJHFrenchJA, et al.Operational classification of seizure types by the International League Against Epilepsy: position paper of the ILAE Commission for Classification and Terminology. Epilepsia2017; 58: 522–530.
17.
PentapatiSSDebnathDJ. Updated BG Prasad’s classification for the year 2022. J Fam Med Prim Care2023; 12: 189–190.
18.
ToussaintAHüsingPGumzA, et al.Sensitivity to change and minimal clinically important difference of the 7-item Generalized Anxiety Disorder Questionnaire (GAD-7). J Affect Disord2020; 265: 395–401.
19.
MohammadiMRPourdehghanPMostafaviSA, et al.Generalized anxiety disorder: prevalence, predictors, and comorbidity in children and adolescents. J Anxiety Dis2020; 73: 102234.
20.
HarshaGTAshok KumarKS. A study to assess the anxiety among the adolescents suffering from epilepsy at a tertiary care hospital in Mysore, Karnataka. Int Clin Psych2018; 6: 52–56.
21.
McEvoyPMGroveRSladeT. Epidemiology of anxiety disorders in the Australian general population: findings of the 2007 Australian National Survey of Mental Health and Wellbeing. Aust N Z J Psych2011; 45: 957–967.
22.
BeesdoKKnappeSPineDS. Anxiety and anxiety disorders in children and adolescents: developmental issues and implications for DSM-V. Psych Clin2009; 32: 483–524.
23.
LerayECamaraADrapierD, et al.Prevalence, characteristics and comorbidities of anxiety disorders in France: results from the Mental Health in General Population‖ survey (MHGP). Eur Psych2011; 26: 339–345.
24.
GuptaGKesriRGoyalS, et al.Comorbid depression and anxiety in patients of epilepsy. Ann Indian Psych2022; 6: 137–141.
25.
ReillyCAgnewRNevilleBG. Depression and anxiety in childhood epilepsy: a review. Seizure2011; 20: 589–597.
26.
OguzAKurulSDirikE, et al.Relationship of epilepsy-related factors to anxiety and depression scores in epileptic children. J Child Neurol2002; 17: 37–40.