Using a flap in a large wound with a very small area of exposed vital structures may be an excessive intrusion and cause unnecessary donor site morbidity. Dermal matrix (DuraGen) was applied onto critical areas where bone or tendons were exposed and a split skin graft was placed thereon. All patients had satisfactory wound closure without the need for a flap. DuraGen appears to be a safe, single-stage alternative, to a flap for the healing of complex wounds.
ShoresJTNguyenDQAGonzalezSR, et al.Infectious complications associated with the use of integra: a systematic review of the literature. Plast Reconstr Surg Glob Open2020; 8: e2869. PMID: 32802634; PMCID: PMC7413764.
2.
HamdanAAl-ChalabiMWan SulaimanW. Integra: an alternative option for reconstruction of extensive finger defects with exposed bones. Cureus2021; 13: e16223.
PhamCGreenwoodJClelandH, et al.Bioengineered skin substitutes for the management of burns: a systematic review. Burns2007; 33: 946–957.
5.
van ZuijlenPPVloemansJFvan TrierAJ, et al.Dermal substitution in acute burns and reconstructive surgery: a subjective and objective long-term follow-up. Plast Reconstr Surg2001; 108: 1938–1946.
6.
PhilandrianosCAndrac-MeyerLMordonS, et al.Comparison of five dermal substitutes in full-thickness skin wound healing in a porcine model. Burns2012; 38: 820–829.
7.
RichtersCDPirayeshAHoeksemaH, et al.Development of a dermal matrix from glycerol preserved allogeneic skin. Cell Tissue Banking2008; 9: 309–315. [PubMed:18491218]
8.
LouRBHickersonWL.The use of skin substitutes in hand burns. Hand Clin2009; 25: 497–509. [PubMed:19801123]
9.
MoiemenNSVlachouEStaianoJJ, et al.Reconstructive surgery with Integra dermal regeneration template: Histologic study, clinical evaluation, and current practice. Plast Reconstr Surg2006; 117: 160S–174S. [PubMed:16799385]
10.
RehimSASinghalMChungKC.Dermal skin substitutes for upper limb reconstruction: Current status, indications, and contraindications. Hand Clin2014; 30: 239–252, vii.
11.
BohacMDanisovicLKollerJ, et al.What happens to an acellular dermal matrix after implantation in the human body? A histological and electron microscopic study. Eur J Histochem2018; 62: 2873.
12.
PetrieKCoxCTBeckerBC, et al.Clinical applications of acellular dermal matrices: A review. Scars Burn Heal2022; 8: 1–32.
13.
SchickBWolfGRomeikeBF, et al.Dural cell culture. A new approach to study duraplasty. Cells Tissues Organs2003; 173: 129–137. PubMed.
14.
van WingerdenJJLapidOvan der HorstCM. Bridging phenomenon—Simplifying complex ear reconstructions. Head Neck2014; 36: 735–738. Epub 2013 Nov 7. PMID: 23970464.
WangWChenDSGuoZD, et al.Artificial dermis combined with skin grafting for the treatment of hand skin and soft tissue defects and exposure of bone and tendon. World J Clin Cases2023; 11: 8003–8012. PMID: 38075574 DOI: 10.12998/wjcc.v11.i33.8003.
17.
SternRMcPhersonMLongakerMT. Histologic study of artificial skin used in the treatment of full-thickness thermal injury. J Burn Care Rehabil1990; 11: 7–13.
18.
MuangmanPEngravLHHeimbachDM, et al.Complex wound management utilizing an artificial dermal matrix. Ann Plast Surg2006; 57: 199–202.
19.
SchiavonMFrancesconMDrigoD, et al.The use of Integra dermal regeneration template versus flaps for reconstruction of full-thickness scalp defects involving the Calvaria: a cost–benefit analysis. Aesth Plast Surg2016; 40: 901–907.
20.
HopMJBloemenMCvan BaarME, TOPSKIN Study Group, al.Cost study of dermal substitutes and topical negative pressure in the surgical treatment of burns. Burns2014; 40: 388–396.