Our retrospective cohort study of the effects of radiotherapy delay on the oncological outcome of breast cancer patients showed a prolonged radiotherapy waiting interval was associated with a statistically significant increase in the 3-year breast cancer-specific mortality. This research should stimulate setting up protocols geared towards minimizing delays.
WarnerWAMorrisonRLLeeTY, et al.Associations among ancestry, geography and breast cancer incidence, mortality, and survival in Trinidad and Tobago. Cancer Med2015; 4: 1742–1753.
2.
NaraynsinghVHariharanSDanD,et al.Trends in breast cancer mortality in Trinidad and Tobago—a 35-year study. Cancer Epidem2010; 34: 20–23.
3.
Early Breast Cancer Trialists’ Collaborative Group. Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: an overview of the randomized trials. Lancet2005; 366: 2087–2106.
4.
IslamSAzizIShahJ, et al.The impact of breast clinic on the mastectomy and axillary clearance rates at a tertiary hospital in an Eastern Caribbean Nation: a comparative study. Internat J Breast Cancer2019; 2019: 8018242.
5.
HollandRConnollyJLGelmanR, et al.The presence of an extensive intraductal component following a limited excision correlates with prominent residual disease in the remainder of the breast. J Clin Oncol1990; 8: 113–118.
6.
World Health Organization. Health situation in the Americas: Basic indicators. I apologize, this was the full citation given for this study.
7.
CaponioRCilibertiMPGrazianoG, et al.Waiting time for radiation therapy after breast-conserving surgery in early breast cancer: a retrospective analysis of local relapse and distant metastases in 615 patients. Eur J Med Res2016; 21: 32.
8.
FletcherGH. Implications of the density of clonogenic infestation in radiotherapy. Int J Radiat Oncol Biol Phys1986; 12: 1675–1680.
9.
ClarkeDHLêMGSarrazinD, et al.Analysis of local-regional relapses in patients with early breast cancers treated by excision and radiotherapy: experience of the Institut Gustave-Roussy. Int J Radiat Oncol Biol Phys1985; 11: 137–145.
10.
MikeljevicJSHawardRJohnstonC, et al.Trends in postoperative radiotherapy delay and the effect on survival in breast cancer patients treated with conservation surgery. Br J Cancer2004; 90: 1343–1348.
11.
OlivottoIALesperanceMLTruongPT, et al.Intervals longer than 20 weeks from breast-conserving surgery to radiation therapy are associated with inferior outcome for women with early-stage breast cancer who are not receiving chemotherapy. J Clin Oncol2009; 27: 16–23.