Erythema nodosum leprosum (ENL) is an immunological complication of leprosy seen in 50% of lepromatous and 10% of borderline lepromatous leprosy. It usually presents as a multisystem disease with papulo-nodular skin lesions and fever. Arthralgia or arthritis is a common initial presentation of erythema nodosum leprosum. Pure rheumatologic presentation of lepromatous leprosy complicated by erythema nodosum leprosum is extremely rare, mimics connective tissue disease and is treated with steroids.
PocaterraLJainSReddyR, et al.Clinical course of erythema nodosum leprosum: an 11-year cohort study in Hyderabad, India. Am J Trop Med Hyg2006; 74: 868–879.
2.
NeryJASchreuderPAde MattosPC, et al.Hansen’s disease in a general hospital: uncommon presentations and delay in diagnosis. J Eur Acad Dermatol Venereol2009; 23: 150–156.
3.
WakhluASawlaniKKHimanshuD. Rheumatological manifestations of Hansen's disease. Indian J Rheumatol2018; 13: 14–19.
4.
KarthikeyanK. Histoid leprosy. Am J Trop Med Hyg2015; 92: 1085–1086. PMCID: PMC4458807. PMID: 26041788
