Respiratory distress contributes to the high burden of preterm mortality globally. The aim of our study was to evaluate the use of low-cost Bubble Continuous Positive Airway Pressure devices for treating respiratory distress and their outcomes in preterm infants weighing <1500g. Data was extracted from admission records of 211 infants over two distinct 4-year periods before and after introduction of bCPAP. With survival rates of 26.7% and 61.8% in the pre and post bCPAP eras respectively, significantly improved outcomes were found.
BlencoweHCousensSChouD, et al.Born too soon: the global epidemiology of 15 million preterm births. Reprod Health2013; 10: S2.
2.
BlencoweHCousensSOestergaardMZ, et al.National, regional, and worldwide estimates of preterm birth rates in the year 2010 with time trends since 1990 for selected countries: a systematic analysis and implications. Lancet2012; 379: 2162–2172. 2012/06/12.
3.
VictoraJDSilveiraMFTonialCT, et al.Prevalence, mortality and risk factors associated with very low birth weight preterm infants: an analysis of 33 years. J Pediatr (Rio J)2020; 96: 327–332. 2018/12/15.
4.
DyerJ. Neonatal respiratory distress syndrome: tackling A worldwide problem. P T2019; 44: 12–14.
5.
PanRChenGYWangJ, et al.Bi-level nasal positive airway pressure (BiPAP) versus nasal continuous positive airway pressure (CPAP) for preterm infants with birth weight less than 1500 g and respiratory distress syndrome following INSURE treatment: a two-center randomized controlled trial. Curr Med Sci2021; 41: 542–547. 2021/06/16.
6.
RamaswamyVVMoreKRoehrCC, et al.Efficacy of noninvasive respiratory support modes for primary respiratory support in preterm neonates with respiratory distress syndrome: systematic review and network meta-analysis. Pediatr Pulmonol2020; 55: 2940–2963. 2020/08/08.
7.
ThukralASankarMJChandrasekaranA, et al.Efficacy and safety of CPAP in low- and middle-income countries. J Perinatol2016; 36: S21–S28.
8.
IyerRJayashreeM. Bubble CPAP in acute bronchiolitis. Indian Pediatr2018; 55;437. 2018/05/31.
9.
KawazaKMachenHEBrownJ, et al.Efficacy of a low-cost bubble CPAP system in treatment of respiratory distress in a neonatal ward in Malawi. Malawi Med J2016; 28: 131–137. 2016/11/30.
10.
LarsenSVPoulsenA. Low-Cost bubble-CPAP treatment of a severe case of pneumonia in a low- and middle-income country: a case report on the importance of optimizing bubble-CPAP setup. J Trop Pediatr2021; 67(3): fmaa049. DOI: 10.1093/tropej/fmaa049.
11.
FalkMDonaldssonSDrevhammarT. Infant CPAP for low-income countries: an experimental comparison of standard bubble CPAP and the pumani system. PLoS One2018; 13: e0196683. 2018/05/17.
12.
ChenADeshmukhAARichards-KortumR, et al.Cost-effectiveness analysis of a low-cost bubble CPAP device in providing ventilatory support for neonates in Malawi - a preliminary report. BMC Pediatr2014; 14: 288. 2014/11/26.
13.
OkelloFEgiruEIkirorJ, et al.Reducing preterm mortality in eastern Uganda: the impact of introducing low-cost bubble CPAP on neonates <1500 g. BMC Pediatr2019; 19: 311. 2019/09/06.
14.
RezzonicoRCaccamoLMManfrediniV, et al.Impact of the systematic introduction of low-cost bubble nasal CPAP in a NICU of a developing country: a prospective pre- and post-intervention study. BMC Pediatr2015; 15: 26. 2015/04/18.
15.
McAdamsRM. Bubble CPAP may be safe and efficacious for neonates in low and middle income countries, but more evidence is needed. Evid Based Med2015; 20: 62. 2015/02/11.
16.
OkonkwoIROkoloAA. Buble CPAP in Nigerian tertiary hospitals; patented and improvised. Niger J Padiatr2016; 43: 286–290.
17.
SilvermanWAAndersenDH. A controlled clinical trial of effects of water mist on obstructive respiratory signs, death rate and necropsy findings among premature infants. Pediatrics1956; 17: 1–10. 1956/01/01.
18.
HedstromABGoveNEMayockDE, et al.Performance of the silverman andersen respiratory severity score in predicting PCO2 and respiratory support in newborns: a prospective cohort study. J Perinatol2018; 38: 505–511.
19.
DagaSMhatreSBorhadeA, et al.Home-Made continuous positive airways pressure device may reduce mortality in neonates with respiratory distress in low-resource setting. J Trop Pediatr2014; 60: 343–347.
20.
ZhuZYuanLWangJ, et al.Mortality and morbidity of infants born extremely preterm at tertiary medical centers in China from 2010 to 2019. JAMA Netw Open2021; 4: e219382. 2021/05/12.
21.
YismawAEGelagayAASisayMM. Survival and predictors among preterm neonates admitted at university of gondar comprehensive specialized hospital neonatal intensive care unit, northwest Ethiopia. Ital J Pediatr2019; 45: 4. 2019/01/09.
22.
YakoobMY. Predictors of survival of very preterm births (born between 23 and 29 weeks' Gestation) at a tertiary care center in karachi, Pakistan: additional multivariate analyses on data from primary cohort. BMC Res Notes2019; 12: 620. 2019/09/25.
23.
TameneAAbejeGAddisZ. Survival and associated factors of mortality of preterm neonates admitted to felege hiwot specialized hospital, Bahir Dar, Ethiopia. SAGE Open Med2020; 8: 2050312120953646. 2020/09/15.
24.
AgbenoEKOsarfoJAshongJ, et al.Determinants of preterm survival in a tertiary hospital in Ghana: a ten-year review. PLoS One2021; 16: e0246005. 2021/01/23.
25.
Garcia-Munoz RodrigoFFabresJTapiaJL, et al.Factors associated with survival and survival without Major morbidity in very preterm infants in two neonatal networks: SEN1500 and NEOCOSUR. Neonatology2021; 118: 289–296. 2021/02/26.
26.
MyhreJImmaculateMOkeyoB, et al.Effect of treatment of premature infants with respiratory distress using low-cost bubble CPAP in a rural African hospital. J Trop Pediatr2016; 62: 385–389. 2016/04/28.
27.
DumpaVKamityRFerraraL, et al. The effects of oral feeding while on nasal continuous positive airway pressure (NCPAP) in preterm infants. J Perinatol2020; 40(6): 990–915. DOI: 10.1038/s41372-020-0632-2.
