Leptospirosis presents in a biphasic manner: an early leptospiraemic phase and a late immune phase. In its severe form, it presents with multi-organ failure, also known as Weil's disease. Stevens-Johnson syndrome (SJS) is an autoimmune hypersensitive reaction leading to diffuse fluid filled vesicle formation with detachment of skin and mucous membrane. Though SJS is triggered by different infections and drugs, its association with leptospirosis is not frequently reported. Here we present such a case.
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References
1.
WHO. Leptospirosis burden epidemiology reference group (LERG). Global burden of leptospirosis. Geneva: World Health Organization, 2010.
2.
CorreiaODelgadoLRamosJP,et al.Cutaneous T-cell recruitment in toxic epidermal necrolysis. Further evidence of CD8+ lymphocyte involvement. Arch Dermatol1993; 129: 466–468. PMID: 8466217.
3.
ChungWHHungSIYangJY, et al.Granulysin is a key mediator for disseminated keratinocyte death in stevens-johnson syndrome and toxic epidermal necrolysis. Nat Med2008; 14: 1343–1350.. Epub 2008 Nov 23. PMID: 19029983.
4.
KlimpelGRMatthiasMAVinetzJM. Leptospira interrogans activation of human peripheral blood mononuclear cells: preferential expansion of TCRγδ+ T cells vs TCRαβ+ T cells. J Immunol2003; 171: 1447–1455.
