We aimed to determine the outcome of bacteriologically confirmed drug-resistant (DR) tuberculosis (TB) in 174 children. We found that DR-TB infected children have nonetheless a high treatment completion rate with a low incidence of fatality and treatment failure. Reversible adverse drug reactions are common during therapy.
World Health Organization. Definitions and reporting framework for tuberculosis – 2013 revision: updated December 2014 and January 2020. World Health Organization, https://apps.who.int/iris/handle/10665/79199 (2013, accessed 6 October 2021).
2.
GoyalVKadamVNarangP, et al. Prevalence of drug-resistant pulmonary tuberculosis in India: systematic review and meta-analysis. BMC Public Health2017; 17: 817.
ShahMAShahI. Increasing prevalence of pediatric drug-resistant tuberculosis in Mumbai, India, and its outcome. Pediatr Infect Dis J2018; 37: 1261–1263.
Medecins Sans Frontieres – Field Research. Research Protocol – Effectiveness of a simplified short regimen for multidrug resistant tuberculosis treatment in Karakalpakstan, Uzbekistan, http://fieldresearch.msf.org/msf/handle/10144/322296 (accessed 13 May 2016).
9.
AhujaSDAshkinDAvendanoM, et al. Multidrug resistant pulmonary tuberculosis treatment regimens and patient outcomes: an individual patient data meta-analysis of 9,153 patients. PLoS Med2012; 9: e1001300.
10.
SeddonJAHesselingACGodfrey-FaussettP, et al. High treatment success in children treated for multidrug-resistant tuberculosis: an observational cohort study. Thorax2014; 69: 458–464.
11.
SchlugerNWLawrenceRMMcGuinessG, et al. Multidrug-resistant tuberculosis in children: two cases and a review of the literature. Pediatr Pulmonol1996; 21: 138–142.
12.
MukherjeeJSJosephJKRichML, et al.Clinical and programmatic considerations in the treatment of MDR-TB in children: a series of 16 patients from Lima, Peru. Int J Tuberc Lung Dis2003; 7: 637–644.
13.
SeddonJATheeSJacobsK, et al. Hearing loss in children treated for multidrug-resistant tuberculosis. J Infect2013; 66: 320–329.
