Uric acid is a metabolic product of nucleic acid and protein. Hyperuricemia results from failure or lack of urate oxidase. We present a case of a 61-year-old man with a painless forearm swelling, from which uric acid crystals were found on cytology. There were also septate fungal hyphae with morphology of Aspergillus, which has the source of the uric acid. Serum uric acid levels in our patient were normal.
ShabnamWA. Microbial urate oxidase as anti hyperuricemic agent: current scenario and future prospects. Pharmaceut Chem J2018; 5: 166–180.
2.
JohnsonRJLanaspaMAGaucherEA. Uric acid: a danger signal from the RNA world that may have a role in the epidemic of obesity, metabolic syndrome, and cardiorenal disease: evolutionary considerations. Semin Nephrol2011; 31: 394–399.
3.
KhadeSSrivastavaSK. Urate oxidase and its clinical applications. Int J Biol Med Res2015; 6: 5211–5215.
4.
RetailleauPColloc'hNVivarèsD, et al.Urate oxidase from Aspergillus flavus: new crystal-packing contacts in relation to the content of the active site. Acta Crystallogr D Biol Crystallogr2005; 61: 218–229.
5.
CostantiniAV. Fungalbionics: a new concept of the etiology of gout, hyperuricemia and their related diseases. Adv Exp Med Biol1989; 253A: 261–268.
6.
El-Ahmasy El-NaggarNHarounSA, et al.Mathematical modeling for bioprocess optimization of a protein drug, uricase, production by Aspergillus welwitschiae strain 1–4. Scientif Rep2019; 9: 12971–12971.