Diffuse cutaneous leishmaniasis is a rare chronic infectious disease, associated with Leishmania mexicana and L. amazonensis, presenting as multiple non-ulcerative painless nodules, with a tendency to relapse soon after treatment. We report a case of a 56-year-old Mexican woman exhibiting nodular lesions, plaques, crusts and scars involving the whole body. A solitary nodule was present at the junction between hard and soft palates. Diffuse cutaneous leishmaniasis is a disfiguring disease resulting in severe scarring if untreated.
World Health Organization. Control of the leishmaniases. World Health Organ Tech Rep Ser2010; 949: 22–26.
2.
Pan American Health Organization. Epidemiological Report of the Americas. Rep Leishmaniases 2015; 3: 2–5. Available at: http://new.paho.org/leishmaniasis.
3.
AlvarJVélezIDBernC, et al.Leishmaniasis worldwide and global estimates of its incidence. PLoS One2012; 7: e35671–e35671.
4.
Rodríguez-RojasJJRodríguez-MorenoÁBerzunza-CruzM, et al.Ecology of phlebotomine sandflies and putative reservoir hosts of leishmaniasis in a border area in Northeastern Mexico: implications for the risk of transmission of Leishmania mexicana in Mexico and the USA. Parasite2017; 24: 33–33. . doi:10.1051/parasite/2017034.
5.
MurrayHWBermanJDDaviesCR, et al.Advances in leishmaniasis. Lancet2005; 366: 1561–1577.
6.
Hernández-RuizJSalaiza-SuazoNCarradaG, et al.CD8 cells of patients with diffuse cutaneous leishmaniasis display functional exhaustion: the latter is reversed, in vitro, by TLR2 agonists. PLoS Negl Trop Dis2010; 4: e871–e871.
7.
RealFMortaraRA. The diverse and dynamic nature of Leishmania parasitophorous vacuoles studied by multidimensional imaging. PLoS Negl Trop Dis2012; 6: e1518–e1518.
8.
Camacho-OrtizAMuñoz-GarzaFZBeckerI, et al.Transient success using prolonged treatment with miltefosine for a patient with diffuse cutaneous Leishmaniasis infected with Leishmania mexicana mexicana. Am J Trop Med Hyg2013; 88(1): 153–156.
