Are incidentally detected gall bladder cancers really incidental? A report of two cases from a developing nation

Abstract

Gallbladder cancer (GBC) is a rare gastrointestinal tumour. It occurs in women with pre-existing cholelithiasis. These tumours pose therapeutic as well as diagnostic challenges to treating clinicians. Early suspicion and optimal surgery for suspected GBC results in the best outcome. We describe two cases of metastatic GBC initially treated by simple cholecystectomy for gallstone despite disease pointers towards a malignant pathology. Subsequent presentation was with histopathologically proven metastatic GBC. In an area of high gallsone prevalence, a high index of suspicion and correct management of patients with suspicion of GBC is mandatory.

Keywords

Gallbladder cancer radical cholecystectomy laparoscopic cholecystectomy

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References

Misra

Chaturvedi

Misra

et al.

Carcinoma of the gallbladder. Lancet Oncol 2003; 4: 167–176.

Sharma

Gupta

et al.

Gallbladder cancer epidemiology, pathogenesis and molecular genetics: Recent update. World J Gastroenterol 2017; 23: 3978–3998.

Donohue

. Present status of the diagnosis and treatment of gallbladder carcinoma. J Hepatobiliary Pancreat Surg 2001; 8: 530–534.

Beltz

Condon

. Primary carcinoma of the gallbladder. Ann Surg 1974; 180: 180–184.

Fong

Brennan

Turnbull

et al.

Gallbladder cancer discovered during laparoscopic surgery. Potential for latrogenic tumor dissemination. Arch Surg 1993; 128: 1054–1056.

Albores-Saavedra

Alcantra-Vazquez

Cruz-Ortiz

et al.

The precursor lesions of invasive gallbladder carcinoma. Hyperplasia, atypical hyperplasia and carcinoma in situ. Cancer 1980; 45: 919–927.

Kinoshita

Nagata

Hirohashi

et al.

Carcinoma of the gallbladder with an anomalous connection between the choledochus and the pancreatic duct. Report of 10 cases and review of the literature in Japan. Cancer 1984; 54: 762–769.

Gupta

Anjum

et al.

A comprehensive review on primary gallbladder tuberculosis. Pol Przegl Chir 2018; 90: 10–12.

Rooholamini

Tehrani

Razavi

et al.

Imaging of gallbladder carcinoma. Radiographics 1994; 14: 291–306.

10.

Anderson

Rice

Pinson

et al.

Fluorodeoxyglucose PET imaging in the evaluation of gallbladder carcinoma and cholangiocarcinoma. J Gastrointest Surg 2004; 8: 90–97.

11.

Zhu

Hong

Hezel

et al.

Current management of gallbladder carcinoma. Oncologist 2010; 15: 168–181.

12.

Goere

Wagholikar

Pessaux

et al.

Utility of staging laparoscopy in subsets of biliary cancers. Surg Endosc 2006; 20: 721–725.

13.

Yamaguchi

Chijiiwa

Ichimiya

et al.

Gallbladdercarcinoma in the era of laparoscopic cholecystectomy. Arch Surg 1996; 131: 981–984.

14.

Muratore

Polastri

Capussotti

. Radical surgery for gallbladder cancer: current options. Eur J Surg Oncol 2000; 26: 438–443.

15.

Shimada

Endo

Togo

et al.

The role of lymph node dissection in the treatment of gallbladder carcinoma. Cancer 1997; 79: 892–899.

16.

Sirohi

Mitra

Jagannath

et al.

Neoadjuvant chemotherapy in patients with locally advanced gallbladder cancer. Future Oncol 2015; 11: 1501–1509.