We report the first case of haemophagocytic lymphohistiocytosis (HLH) in a neonate secondary to primary Dengue virus infection. This neonate presented in the third week of life with fever, shock and hepatosplenomegaly and was diagnosed to have Dengue infection by serology and HLH was confirmed on bone marrow.
Hemophagocytic Lymphohistiocytosis Study Group. Histiocyte Society. Treatment protocol of the second international HLH study (HLH 2004), Pitman, NJ: Histiocyte Society, 2004.
2.
RajagopalaSSinghN. Diagnosing and treating hemophagocytic lymphohistiocytosis in the tropics: systematic review from the Indian subcontinent. Acta Med Acad2012; 41: 161–174.
3.
IsaacsHJr. Fetal and neonatal histiocytoses. Pediatr Blood Cancer2006; 47: 123–129.
4.
RamachandranBBalasubramanianSAbhishekN. Profile of hemophagocytic lymphohistiocytosis in children in a tertiary care hospital in India. Indian Pediatr2011; 48: 31–35.
5.
JankaGELehmbergK. Hemophagocytic lymphohistiocytosis: pathogenesis and treatment. Hematology Am Soc Hematol Educ Program2013; 2013: 605–611.
