Epidemic dropsy (ED) is caused due to intoxication with Argemone mexicana. Here we report a case series of three families, all of whom were residents of Uttar Pradesh, India, who presented in August 2013 with all the classical features of ED. We aim to highlight the importance of this malady even though the sale of unbottled mustard oil is illegal in India.
DasMKhannaSK. Clinicoepidemiological, toxicological, and safety evaluation studies on argemone oil. Crit Rev Toxicol1997; 27: 273–297.
2.
LyonIB. Textbook of Medical Jurisprudence for India, 1st edn. Kolkata: Thacker, Spink & Co.;, 1889.
3.
DasMBabuKReddyNPSrivastavaLM. Oxidative damage of plasma proteins and lipids in epidemic dropsy patients: alterations in antioxidant status. Biochim Biophys Acta2005; 1722: 209–217.
4.
DhayalGLAgarwalHMathurAMathurSKishoriaNJainS. Case report of a small outbreak of epidemic dropsy. J Indi Med Assoc2013; 111: 200–201.
5.
MeakerRE. Argemone Mexicana seed poisoning. South African Med J1951; 24: 331–333.
6.
NarasimhanCTJGThomasGIsraelJRaoPSPulimoodBM. Epidemic dropsy in Andhra Pradesh due to contaminated ghee. J Assoc Physicians India1991; 39: 749–750.
7.
SoodNNSachdevMSMohanMGuptaSKSachdevHP. Epidemic dropsy following transcutaneous absorption of Argemone mexicana oil. Trans R Soc Trop Med Hyg1985; 79: 510–512.
8.
LalRBDasguptaAC. Investigations into the epidemiology of epidemic dropsy. Incidence by season. Ind J Med Res1942; 30: 145–145.
9.
ReddyNPDasM. Interaction of sanguinarine alkaloid, isolated from argemone oil, with hepatic cytochrome p450 in rats. Toxicol Mech Methods2008; 18: 635–643.
10.
EruvaramNRDasM. Phenotype of hepatic xenobiotic metabolizing enzymes and CYP450 isoforms of sanguinarine treated rats: effect of P450 inducers on its toxicity. Toxicol Mech Methods2009; 19: 510–517.
11.
SeifenEAdamsRJRiemerRK. Sanguinarine: a positive inotropic alkaloid which inhibits cardiac Na+, K+ -ATPase. Eur J Pharmacol1979; 60: 373–377.
12.
MohanMSoodNNDayalNSachdevaMSChandrashekharGGupaMS. Ocular and clinico-epidemiological study of epidemic dropsy. Indian J Med Res1984; 80: 449–456.
13.
RathoreMK. Ophthalmological study of epidemic dropsy. Br J Ophthalmol1982; 66: 573–575.
14.
SharmaBDMalhotraSBhatiaVRatheeM. Epidemic dropsy in India. Postgrad Med J1999; 75: 657–661.