This paper discusses the so-called non-interference assumption (NIA) grounding causal inference in trials in both medicine and the social sciences. It states that for each participant in the experiment, the value of the potential outcome depends only upon whether she or he gets the treatment. Drawing on methodological discussion in clinical trials and laboratory experiments in economics, I defend the necessity of partial forms of blinding as a warrant of the NIA, to control the participants’ expectations and their strategic interactions with the experimenter.
BanerjeeAbhijit V.DufloEsther. 2009. “The Experimental Approach to Development Economics.” Annual Review of Economics1 (1): 151-78.
2.
BangHeejungNiLiyunDavisClarence E.2004. “Assessment of Blinding in Clinical Trials.” Controlled Clinical Trials25 (2): 143-56.
3.
ChouEileenMcConnellMargaretNagelRosemariePlottCharles. 2009. “The Control of Game Form Recognition in Experiments: Understanding Dominant Strategy Failures in a Simple Two Person Guessing Game.” Experimental Economics12:159-179.
4.
ColagiuriBen. 2010. “Participant Expectancies in Double-Blind Randomized Placebo-Controlled Trials: Potential Limitations to Trial Validity.” Clinical Trials7 (3):246-55.
5.
EpsteinSteven. 1996. Impure Science: AIDS and the Politics of Knowledge. Berkeley: University of California Press.
6.
EvansDylan. 2004. Placebo: Mind over Matter in Modern Medicine. New York: Oxford University Press.
7.
FergussonDeanGlassKathleen CranleyWaringDuffShapiroStan. 2004. “Turning a Blind Eye: The Success of Blinding Reported in a Random Sample of Randomised, Placebo Controlled Trials.” British Medical Journal328 (7437): 432.
8.
GerberAlan S.GreenDonald P.2012. Field Experiments: Design, Analysis, and Interpretation. New York: W.W. Norton.
9.
GluudLise L.2006. “Bias in Clinical Intervention Research.” American Journal of Epidemiology163 (6): 493-501.
10.
HeckmanJames J.1992. “Randomization and Social Policy Evaluation.” In Evaluating Welfare and Training Programs, edited by ManskiC. F.GarfinkelI.201-30. Cambridge, MA: Harvard University Press.
11.
HowickJeremy. 2011. The Philosophy of Evidence-Based Medicine. London: Wiley-Blackwell.
12.
HróbjartssonAForfangE.HaahrM. T.Als-NielsenB.Brorson.S.2007. “Blinded Trials Taken to the Test: An Analysis of Randomized Clinical Trials that Report Tests for the Success of Blinding.” International Journal of Epidemiology36 (3): 654-63.
13.
KolahiJafarBangHeejungParkJongbae. 2009. “Towards a Proposal for Assessment of Blinding Success in Clinical Trials: Up-to-Date Review.” Community Dentistry and Oral Epidemiology37 (6): 477-84.
14.
OrtmannAndreasHertwigRalph. 2002. “The Costs of Deception: Evidence from Psychology.” Experimental Economics5 (2): 111-31.
15.
PetrynaAdriana. 2009. When Experiments Travel: Clinical Trials and the Global Search for Human Subjects. Princeton: Princeton University Press.
16.
Preference Collaborative Review Group. 2008. “Patients’ Preferences within Randomised Trials: Systematic Review and Patient Level Meta-Analysis.” British Medical Journal337. doi:10.1136/bmja1864.
17.
ReesJudy R.WadeTimothy J.LevyDeborah A.JrColfordJohn M.HiltonJoan F.2005. “Changes in Beliefs Identify Unblinding in Randomized Controlled Trials: A Method to Meet CONSORT Guidelines.” Contemporary Clinical Trials26 (1): 25-37.
18.
SchulzKenneth F.GrimesDavid A.AltmanDouglas G.Hayes.Richard J.1996. “Blinding and Exclusions after Allocation in Randomised Controlled Trials: Survey of Published Parallel Group Trials in Obstetrics and Gynaecology.” British Medical Journal312 (7033): 742-44.
19.
SchulzKenneth F.ChalmersIainAltman.Douglas G.2002. “The Landscape and Lexicon of Blinding in Randomized Trials.” Annals of Internal Medicine136 (3): 254-59.
20.
SchulzKenneth F.ChalmersIainHayesRichard J.Altman.Douglas G.1995. “Empirical Evidence of Bias.” The Journal of the American Medical Association273 (5): 408-12.
21.
TeiraDavidReissJulian. Forthcoming. “Causality, Impartiality and Evidence-Based Policy.” In Mechanism and Causality and Biology and Economics, edited by ChaoH.-K.ChenS.-T.MillsteinR.Berlin: Springer.
