Abstract
To develop cotton derivatives with prolonged antibacterial activity, cotton is derivatized to cotton xanthate (CX) and coupled with metronidazole (Mz) by means of chelate bonding in the presence of Cu(II) using one- and two-bath processes. The effects of coupling methods, concentration, [Mz]/[Cu(II)] ratio, and reaction time on the formation of CX-Cu(II)-Mz are investigated at 10°C. In the one-bath process where CX is treated with a solution of the Cu(II)-Mz complex, binding of Mz takes place readily and rapidly and increases with a higher [Mz]/[Cu(II)] ratio. In the two-bath process, binding of Mz is much lower than in one bath. Release of Mz from CX-Cu(II)-Mz prepared from the one-bath process is investigated by the flow method and takes place steadily during the first 3 hours. The extent of release reaches 65-99% in 20 hours, depending on the concentration of Cu(II) and Mz used to form CX-Cu(II)-Mz. Antibacterial activity of CX-Cu(II)-Mz is tested against G(+) S. aureus, B. subtilis, and G(-) E. coli., and lasts longer than that of free Mz.
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