Abstract
We extend our basic discrete-event model of Plasmodium falciparum malaria to encom pass circumstances in which multiple pheno typic variants of the parasite circulate within interacting human and mosquito populations, and we compare a version in which variants behave independently to one in which they in teract through shared host immune responses. Relative to the standard hypothesis of statisti cal independence, frequencies of mixed-pheno type infection in humans were as expected in the independent-immunity version and much less than expected in the cross-immunity ver sion ; in both versions, however, such frequen cies in mosquitoes were much greater than expected.
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