Abstract
The paper summarizes guidelines for applying computer simulation to life sciences research. It provides brief answers to the following questions:
To what extent can problems be rigorously solved by simu lation—especially complicated problems—and how is this to be done?
What can a given simulation study be expected to accomplish, and when can it be considered complete?
Of what value are the properties of a model in understanding the living system under study?
What should be the proper interaction between simulationists and subject-matter experts in a collaboration?
What constitutes ethical conduct for a simulationist?
To what extent should the same person do both experiments and simu lation?
How should simulationists be trained?
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