The Role of Endothelin-1 in Cardiovascular Physiology and Pathophysiology

Yanagisawa M Kurihara H Kimura S A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature 1988; 332: 411–415.

Xu D Enoto N Giaid A Slaughter C ECE-1: A membrane-bound metalloprotease that catalyses the proteolytic activation of big endothelinl. Cell 1994;78: 473–485.

Haynes WG Webb DJ . The endothelin family of peptides: Local hormones with diverse roles in health and disease? Clin Sci 1993; 84: 485–500.

Haynes WG Webb DJ . Venoconstriction to endothelin-1 in humans: The role of calcium and potassium channels. Am J Physiol 1993; 265 (Heart Circ. Physiol. 34): H1676–81.

Haynes WG Strachan FE Webb DJ . Endothelin ET_A and ET_B receptors cause vasoconstriction of human resistance and capacitance vessels in vivo. Circulation 1995; (in press).

Haynes WG Davenport AP Webb DJ . Endothelin: Progress in physiology and pharmacology. Trends Pharmacol Sci 1993; 14: 225–228.

Clarke JG Benjamin N Larkin SW Webb DJ Davies GJ Maseri A . Endothelin is a potent long-lasting vasoconstrictor in men. Am J Physiol 1989; 257: H2033–H2035.

Vierhapper H Wagner O Nowotny P Waldhausl W . Effect of endothelin-1 in man. Circulation 1990; 81: 1415–1418.

Haynes WG Webb DJ . Endothelium dependent modulation of responses to endothelin-1 in human hand veins. Clin Sci 1993; 84: 427–33.

Webb DJ . The pharmacology of human blood vessels in vivo. J Vasc Res 1995 (in press).

Haynes WG Webb DJ . Contribution of endogenous generation of endothelin-1 to basal vascular tone in man. Lancet 1994; 344: 852–854.

Plumpton C Haynes WG Webb DJ Davenport AP . Phosphoramidon inhibits the in vivo conversion of big ET-1 to ET-1 in man. Brit J Pharmacol 1995 (in press).

Watanabe Y Naruse M Monzen C Is big endothelin converted to endothelin-1 in circulating blood? J Cardiovasc Pharmacol 1991; 17 (Suppl 7): S503–S505.

Haynes WG Skwarski KM Wyld PJ Ripke H Webb DJ . (1995). Vasodilator effects of the ET_A/B antagonist, TAK-044, in man. J Cardiovasc Pharmacol 1995 (in press).

Davenport AP Ashby MJ Easton P A sensitive radioimmunoassay measuring endothelin-like immunoreactivity in human plasma: Comparison of levels in patients with essential hypertension and normotensive control subjects. Clin Sci 1990; 78:261–264.

Haynes WG Hand MF Johnstone HA Padfield PL Webb DJ . Direct and sympathetically mediated venoconstriction in essential hypertension: Enhanced responses to endothelin. J Clin Invest 1994; 94: 1359–1364.

Lerman A Edwards BS Hallett JW Circulating and tissue endothelin immunoreactivity in advanced atherosclerosis. N Engl J Med 1991; 325: 997–1001.

McMurray JJ Ray SG Abdullah I Dargie HD Morton JJ . Plasma endothelin in chronic heart failure. Circulation 1992; 85: 1374–1379.

Wieczorek I Haynes WG Webb DJ Ludlam CA Fox KAA . Raised plasma endothelin in unstable angina and non-Q wave myocardial infarction: Relation to cardiovascular outcome. Br Heart J 1994; 72: 436–41.

Omland T Lie RT Aakvaag A Aarsland T Dickstein K . Plasma endothelin determination as a prognostic indicator of 1-year mortality after acute myocardial infarction. Circulation 1994; 89:1573–1579.

Love MP Haynes WG Webb DJ McMurray JJV . Endothelin converting enzyme (ECE) inhibition is of potential therapeutic benefit in chronic heart failure. Circulation 1995 (in press).

Clozel M Breu V Burri K Pathophysiological role of endothelin revealed by the first orally active endothelin receptor antagonist. Nature 1993; 365: 759–761.

Vallance P Collier J Moncada S . Effects of endothelium-derived nitric oxide on peripheral arteriolar tone in man. Lancet 1989; ii: 997–1000.

Haynes WG Noon JP Walker BR Webb DJ . L-NMMA increases blood pressure in man. Lancet 1993; 342: 931–2.

Douglas SA Meek TD Ohlstein EH . Novel receptor antagonists welcome a new era in endothelin biology. Trends Pharmacol Sci 1994; 15: 313–316.

Webb DJ Haynes WG . Endothelins come of age. Lancet 1993; 342: 1439–1440.