A Policy for Minimising Nsaid Induced Peptic Ulcer

Freston MS Freston JW . Peptic ulcers in the elderly: Unique features and management. Geriatrics 1990; 45: 39–45.

Beardon PHG Brown SV McDevitt DG . Gastrointestinal events in patients prescribed non steroidal anti inflammatory drugs: A controlled study using record linkage in Tayside. Quarterly J Med 1989; 71: 497–505.

Ng J. Ulcer perforation in the elderly and non steroidal anti inflammatory drugs. Lancet 1986; 1: 972.

Permutt RP Cello JP . Duodenal ulcer disease in the hospitalised elderly patient Digest Dis Sci 1982; 27: 1–6.

Shield MJ Fenn GC Kiff P Do differential rates of NSAID-associated gastroduodenal damage exist? Br J Rheumatol 1990; 29(Abs Suppl 1):5.

Graham DY . Prevention of gastroduodenal injury induced by chronic non-steroidal antiinflammatory drug therapy. Gastroenterology 1989; 96: 675–81.

Bardhan KD Griffin WM Fenn GC Prevention and reversal of NSAID-damage by misoprostol. Abstract presented at American Gastroenterological Assoc. Meeting May 19–22 1991. New Orleans.

Soll AH Kurata J McGuigan JE . Ulcers, nonsteroidal and. inflammatory drugs, and related matters. Gastroenterology 1989, 96: 561–8.

Anonymous. CSM Update: Nonsteroidal anti inflammatory drugs and serious gastrointestinal adverse reactions-1. Br Med J 1986; 292: 614.

Fenn GC Robinson GC . Misoprostol — A logical therapeutic approach to gastroduodenal mucosal injury by non steroidal anti inflammatory drugs. J Clin Pharmacy Ther 1991; 16: 385–409.

Fries JF Miller SR Spitz PW Toward an epidemiology of gastropathy associated with non steroidal anti inflammatory drug use. Gastroenterology 1989; 96: 647–655.

Roth SH Bennett RE Mitchell CS Cimetidine therapy in non-steroidal anti-inflammatory drug gastropathy. Arch Intem Med 1987; 147: 1799–1801.

Ehsamillah RSB Page MC Tildesley G Prevention of gastroduodenal damage induced by nonsteroidal anti inflammatory drugs: Controlled trial of ranitidine. Br Med J 1988; 292: 1017–1021.

Graham DY Agrawal NM Roth SH . Prevention of NSAID-induced gastric ulcer with misoprostol: Multicentre, double-blind, placebo controlled trial. Lancet 1988; 2: 1277–80.

Roth S Agrawal N Mahowald M Misoprostol heals gastroduodenal injury in patients with rheumatoid arthritis receiving aspirin. Arch Inter Med 1989; 149: 775–779.

Bolten W. Treatment of NSAID induced gastrointestinal complaints by co-medication with the prostaglandin analogue misoprostol in rheumatoid arthritis patients. A multicentred double-blind placebo controlled study. Aktuelle Rheumatologie 1989; 14: 214–220.

Bolten W Brodenfelt R. Efficacy of misoprostol in the therapy of NSAID induced symptomysand lesions in the upper GI tract under continued NSAID medication. Clin & Experimental Rheumatology 1990: 8(Suppl 4): 59.

Inman WH . In PEM News, Drug Safety Research Unit, Southampton p32, No 7; August 1991.