Cerebrospinal Fluid Angiotensin Converting Enzyme Levels in the Diagnosis of Neurosarcoidosis

Abstract

Cerebrospinal fluid angiotensin converting enzyme (CSF-ACE) level was measured in two patients considered to have neurosarcoidosis, three patients with possible neurosarcoidosis and in 38 control patients suffering from prolapsed intervertebral discs. Both neurosarcoidosis patients had elevated levels (1.8 and 5.4 μmol/l/min) while the possible neurosarcoidosis patients had values similar to the control patients (mean 0.59±0.42 μmol/l/min). We suggest that CSF-ACE values may be of use in some patients as a diagnostic test for neurosarcoidosis and provide a reference range of normal controls.