Refractory peptic ulceration refers to those gastric and duodenal ulcers that are slow to heal despite active treatment. Oxygen-derived free radicals are cytotoxic and promote tissue injury. This report shows that radical scavengers stimulate the healing of refractory peptic ulceration, thus, providing a valuable method for the treatment of such ulceration.
Del MaestroRFThawHHBjorkJPlankerMArforsKE. Free radicals as mediators of tissue injury. Acta Physiol Scand1980; Suppl 492: 43–57.
5.
SalimAS. Role of oxygen-derived free radicals in the mechanism of chronic gastric ulceration in the rat. Implications for cytoprotection. Digestion1989; 43: 113–119.
6.
SalimAS. Role of oxygen-derived free radicals in the mechanism of. acute and chronic duodenal ulceration in the rat. Dig Dis Sci1990; 35: 73–79.
7.
SalimAS. The significance of removing oxygen-derived free radicals in the treatment of acute and chronic duodenal ulceration in the rat. J Pharm Pharmacol1990; 42: 64–67.
8.
ItohMGuthPH. Role of oxygen-derived free radicals in hemorrhagic shock-induced gastric lesions in the rat. Gastroenterology1985; 88: 1162–1167.
9.
MoorhousePCGrootveldMHalliwellBQuinlanJGGutteridgeJMC. Allopurinol and oxypurinol are hydroxyl radical scavengers. FEBS Lett1987; 213: 23–28.