Heavy chain diseases (HCD) are uncommon. We report the first use of recently developed analytical techniques for the assay of immunoglobulin heavy and light chains in the diagnosis and monitoring of a patient with gamma-HCD.
SeligmanM.Heavy chain diseases. In: Delamore IW. Multiple myeloma and other paraproteinaemias. Edinburgh: Churchill-Livingston, 1986: 263–285.
2.
FranklinEC, LowensteinJ, BigelowB, MeltzerM.Heavy chain disease. A new disorder of serum gammaglobulins. Am J Med1964; 37: 332–350.
3.
WhicherJT, WallaceM, FifieldR.Use of immunoglobulin heavy- and light-chain measurements compared with existing techniques as a means of typing monoclonal immunoglobulins. Clin Chem1987; 33: 1771–1773.
4.
NormansellDE. Use of kappa and lambda chain quantitation for the detection of immunoglobulin abnormalities in serum. Diag Clin Immunol1987; 5: 100–103.
5.
KerenDF, WarrenJS, LoweJB. Strategy to diagnose monoclonal gammapathies in serum: high-resolution electrophoresis, immunofixation, and κ/λ quantitation. Clin Chem1988; 34: 2196–2201.
6.
NormansellDE. Cost-effective detection of anomalous immunoglobulins in serum (Editorial). Clin Chem1988; 34: 2193.
7.
FordRP, MitchellPEG, FraserCG. Desirable performance characteristics and clinical utility of immunoglobulin and light-chain assays derived from data on biological variation. Clin Chem1988; 34: 1733–1736.
