The level within the hypothalamic-pituitary axis at which isolated ACTH deficiency occurs, can be more clearly identified by assessing this axis with corticotrophin-releasing factor (CRF) and insulin induced hypoglycaemia. We report a case where lack of response to both tests, suggests a pituitary origin for this rare endocrine deficiency.
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2.
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NakaharaMShibasakiTShizumeK. Corticotrophin-releasing factor test in normal subjects and patients with hypothalamic-pituitary-adrenal disorders. J Clin Endocrinol Metab (1983); 57: 963–968.
4.
TsukadaTNakaiYKohT. Plasma adrenocorticotropin and cortisol responses to ovine corticotropin-releasing factor in patients with adrenocortical insufficiency due to hypothalamic and pituitary disorders. J Clin Endocrinol Metab (1984); 58: 758–760.
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