Twenty-two patients with idiopathic thrombocytopenic purpura were treated with high-dose intravenous immunoglobulin infusions using an intact intravenous immunoglobulin preparation and a product designed for intramuscular administration. Seventeen patients (77%) responded favourably (rise in platelet count to 100 × 109/1 or above). Children responded better than the adults, and the acute cases better than the chronic. Splenectomy and the presence of detectable platelet antibody had no effect on the response rate. Both products induced identical responses.
ImbachPBarandunSd'ApuzzoV. High-dose intravenous gammaglobulin for idiopathic thrombocytopenic purpura in childhood. Lancet1981; 1: 1228–1231
2.
BusselJBHilgartnerMW. Annotation: The use and mechanism of action of intravenous immunoglobulin in the treatment of immune haematologic disease. Br J Haematol1984; 56: 1–7
3.
FehrJHoffmanVKappelerU.Transient reversal of thrombocytopenia in idiopathic thrombocytopenic purpura by high-dose intravenous gammaglobulin. N Engl J Med1982; 306: 1254–1258
4.
NewlandACTreleavenJGMinchintonRMWatersAH. High-dose intravenous IgG in adults with autoimmune thrombocytopenia. Lancet1983; 1: 84–87
5.
AugenerWFriedmannBBrittingerG.Are aggregates of IgG the effective part of high dose immunoglobulin therapy in adult idiopathic thrombocytopenic purpura (ITP)?Blut1985; 50: 249–252
6.
SalamaAMueller-EckhardtCKiefelV.Effect of intravenous immunoglobulin in immune thrombocytopenia. Competitive inhibition of reticuloendothelial system function by sequestration of autologous red blood cells? Lancet1983; 2: 193–195
7.
PetriIBLorinezABerekI.Detection of Fc-receptor blocking antibodies in anti-Rh(D) hyperimmune gammaglobulin. Lancet1984; 2: 1478–1479
8.
TempletonJGCockerJECrawfordRJForwellMASandilandsGP. Fcγ receptor blocking antibodies in hyperimmune and normal pooled gammaglobulin. Lancet1985; 1: 1337
9.
AegkrBorneVon Dem VerheugtFWAOosterhofFVon RieszEDe La RivereBrutel AEngelfrietCP. A simple immunofluorescence test for the detection of platelet antibodies. Br J Haematol1978; 39: 195–207
10.
LeenCLSYapPLMcClellandDBLAtrahHICrawfordRJMitchellR.NonA nonB hepatitis and intravenous immunoglobulin. Lancet1985; 1: 587–588
11.
SchmidtREBuddeESchaferGSoroehmanI.High-dose intravenous gammaglobulin for idiopathic thrombocytopenic purpura. Lancet1981; 2: 475–476
12.
AtrahHICrawfordRJ. Blood group and response to immunoglobulin in immune thrombocytopenia. Lancet1984; 2: 810
13.
MaceyMGSangsterJMNewlandAC. Blood group and response to high dose IgG. Lancet1985; 1: 1445
14.
DelfraissyJFTcherniaGLaurianYWallonCGalanaudPDormontJ.Suppressor cell function after intravenous gammaglobulin treatment in adult chronic idiopathic thrombocytopenic purpura. Br J Haematol1985; 60: 315–322
15.
SultanYKazatchkineMDMaisonneuvePNydeggerUE. Anti-idiotype suppression of autoantibodies to factor VIII (anti-haemophilic factor) by high-dose intravenous gammaglobulin. Lancet1984; 2: 765–768
16.
RomerJSpathPJ. Molecular composition of immunoglobulin preparations and its relation to complement activation. In NydeggerUE, ed. Immuno-haemotherapy: A guide to immunoglobulin prophylaxis and therapy. London: Academic Press1982; 123–130.
